Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance|
|Citation:||Nature Genetics, 2010; 42(5):536-542|
|Publisher:||Nature Publishing Group|
|Kevin L Campbell, Jason E E Roberts, Laura N Watson, Jörg Stetefeld, Angela M Sloan, Anthony V Signore, Jesse W Howatt, Jeremy R H Tame, Nadin Rohland, Tong-Jian Shen, Jeremy J Austin, Michael Hofreiter, Chien Ho, Roy E Weber & Alan Cooper|
|Abstract:||We have genetically retrieved, resurrected and performed detailed structure-function analyses on authentic woolly mammoth hemoglobin to reveal for the first time both the evolutionary origins and the structural underpinnings of a key adaptive physiochemical trait in an extinct species. Hemoglobin binds and carries O2; however, its ability to offload O2 to respiring cells is hampered at low temperatures, as heme deoxygenation is inherently endothermic (that is, hemoglobin-O2 affinity increases as temperature decreases). We identify amino acid substitutions with large phenotypic effect on the chimeric b/d-globin subunit of mammoth hemoglobin that provide a unique solution to this problem and thereby minimize energetically costly heat loss. This biochemical specialization may have been involved in the exploitation of high-latitude environments by this African-derived elephantid lineage during the Pleistocene period. This powerful new approach to directly analyze the genetic and structural basis of physiological adaptations in an extinct species adds an important new dimension to the study of natural selection.|
|Keywords:||Animals; Elephants; Oxygen; Diphosphoglyceric Acids; Hemoglobins; Amino Acid Substitution; Adaptation, Physiological; Evolution, Molecular; Partial Pressure; Models, Molecular; Fossils; Molecular Sequence Data; Cold Temperature; Mammoths|
|Rights:||© 2010 Nature America, Inc. All rights reserved|
|Appears in Collections:||Earth and Environmental Sciences publications|
Australian Centre for Ancient DNA publications
Environment Institute Leaders publications
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.