Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/61822
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dc.contributor.authorFurness, D.en
dc.contributor.authorDekker, G.en
dc.contributor.authorHague, W.en
dc.contributor.authorKhong, T.en
dc.contributor.authorFenech, M.en
dc.date.issued2010en
dc.identifier.citationMutagenesis, 2010; 25(5):489-498en
dc.identifier.issn0267-8357en
dc.identifier.issn1464-3804en
dc.identifier.urihttp://hdl.handle.net/2440/61822-
dc.description.abstractGenome stability is essential for normal foetal growth and development. To date, genome stability in human lymphocytes has not been studied in relation to late pregnancy diseases, such as pre-eclampsia (PE) and intrauterine growth restriction (IUGR), which can be life-threatening to mother and baby and together affect >10% of pregnancies. We performed a prospective cohort study investigating the association of maternal chromosomal damage in mid-pregnancy (20 weeks gestation) with pregnancy outcomes. Chromosome damage was measured using the cytokinesis-block micronucleus cytome (CBMNcyt) assay in peripheral blood lymphocytes. The odds ratio for PE and/or IUGR in a mixed cohort of low- and high-risk pregnancies (N = 136) and a cohort of only high-risk pregnancies (N = 91) was 15.97 (P = 0.001) and 17.85 (P  = 0.007), respectively, if the frequency of lymphocytes with micronuclei (MN) at 20 weeks gestation was greater than the mean + 2 SDs of the cohort. These results suggest that the presence of lymphocyte MN is significantly increased in women who develop PE and/or IUGR before the clinical signs or symptoms appear relative to women with normal pregnancy outcomes. The CBMNcyt assay may provide a new approach for the early detection of women at risk of developing these late pregnancy diseases and for biomonitoring the efficacy of interventions to reduce DNA damage, which may in turn ameliorate pregnancy outcome.en
dc.description.statementofresponsibilityD. L. F. Furness, G. A. Dekker, W. M Hague, T. Y. Khong and M. F. Fenechen
dc.language.isoenen
dc.publisherOxford Univ Pressen
dc.rights© The Author 2010. Published by Oxford University Press on behalf of the UK Environmental Mutagen Society. All rights reserved.en
dc.subjectLymphocytes; Micronuclei, Chromosome-Defective; Humans; Fetal Growth Retardation; Pre-Eclampsia; DNA Damage; Biological Markers; Body Mass Index; Pregnancy Outcome; Odds Ratio; Risk Factors; Cohort Studies; Prospective Studies; Smoking; Cytokinesis; Aging; Pregnancy; Adult; Femaleen
dc.titleIncreased lymphocyte micronucleus frequency in early pregnancy is associated prospectively with pre-eclampsia and/or intrauterine growth restrictionen
dc.typeJournal articleen
dc.identifier.rmid0020098212en
dc.identifier.doi10.1093/mutage/geq032en
dc.identifier.pubid33919-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]en
dc.identifier.orcidHague, W. [0000-0002-5355-2955]en
dc.identifier.orcidKhong, T. [0000-0002-2404-007X]en
dc.identifier.orcidFenech, M. [0000-0002-8466-0991]en
Appears in Collections:Obstetrics and Gynaecology publications

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