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https://hdl.handle.net/2440/61847
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Type: | Journal article |
Title: | Nutrient intake in the bovine during early and mid-gestation causes sex-specific changes in progeny plasma IGF-I, liveweight, height and carcass traits |
Author: | Micke, G. Sullivan, T. Gatford, K. Owens, J. Perry, V. |
Citation: | Animal Reproduction Science, 2010; 121(3-4):208-217 |
Publisher: | Elsevier Science BV |
Issue Date: | 2010 |
ISSN: | 0378-4320 1873-2232 |
Statement of Responsibility: | G.C. Micke, T.M. Sullivan, K.L. Gatford, J.A. Owens and V.E.A. Perry |
Abstract: | Fetal and postnatal growth are mediated by insulin-like growth factors (IGFs) and their binding proteins (IGFBPs). Maternal nutrient intake during gestation can program the postnatal IGF-axis. This may have significant economic implications for beef cattle production. We investigated the effect of high (H=240%) and low (L=70%) levels of recommended daily crude protein (CP) intake for heifers during the first and second trimesters of gestation in a two-by-two factorial design on progeny (n=68) plasma IGF-I, IGF-II, total IGFBP (tIGFBP), postnatal growth and carcass traits. Calves were heavier at birth following high CP diets during the second trimester (P=0.03) and this persisted to 29d. Plasma IGF-I concentrations of males were greater for HL compared to LL (P<0.01) and HH (P>0.04) from 29 to 657d, and for LH compared to LL from 29 until 379d (P=0.02). Exposure to low CP diets during the first trimester resulted in heavier males from 191d onwards (P=0.04) but a tendency for lighter females from 552d onwards (P=0.07) that had lighter carcass weights (P=0.04). Longissimus dorsi cross-sectional area of all carcasses was greater following exposure to low CP diets during the second trimester (P=0.04). Heifer nutrient intake during the first and second trimesters causes persistent and sex-specific programming of progeny plasma IGF-I, postnatal liveweight and carcass weight. Refining heifer nutritional programs during early gestation may optimize production objectives in progeny. |
Keywords: | Cattle Fetal programming IGF Maternal nutrition Metabolites Postnatal growth |
Rights: | © 2010 Elsevier B.V. All rights reserved. |
DOI: | 10.1016/j.anireprosci.2010.05.017 |
Published version: | http://dx.doi.org/10.1016/j.anireprosci.2010.05.017 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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