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Type: Journal article
Title: Nutrient intake in the bovine during early and mid-gestation causes sex-specific changes in progeny plasma IGF-I, liveweight, height and carcass traits
Author: Micke, G.
Sullivan, T.
Gatford, K.
Owens, J.
Perry, V.
Citation: Animal Reproduction Science, 2010; 121(3-4):208-217
Publisher: Elsevier Science BV
Issue Date: 2010
ISSN: 0378-4320
Statement of
G.C. Micke, T.M. Sullivan, K.L. Gatford, J.A. Owens and V.E.A. Perry
Abstract: Fetal and postnatal growth are mediated by insulin-like growth factors (IGFs) and their binding proteins (IGFBPs). Maternal nutrient intake during gestation can program the postnatal IGF-axis. This may have significant economic implications for beef cattle production. We investigated the effect of high (H=240%) and low (L=70%) levels of recommended daily crude protein (CP) intake for heifers during the first and second trimesters of gestation in a two-by-two factorial design on progeny (n=68) plasma IGF-I, IGF-II, total IGFBP (tIGFBP), postnatal growth and carcass traits. Calves were heavier at birth following high CP diets during the second trimester (P=0.03) and this persisted to 29d. Plasma IGF-I concentrations of males were greater for HL compared to LL (P<0.01) and HH (P>0.04) from 29 to 657d, and for LH compared to LL from 29 until 379d (P=0.02). Exposure to low CP diets during the first trimester resulted in heavier males from 191d onwards (P=0.04) but a tendency for lighter females from 552d onwards (P=0.07) that had lighter carcass weights (P=0.04). Longissimus dorsi cross-sectional area of all carcasses was greater following exposure to low CP diets during the second trimester (P=0.04). Heifer nutrient intake during the first and second trimesters causes persistent and sex-specific programming of progeny plasma IGF-I, postnatal liveweight and carcass weight. Refining heifer nutritional programs during early gestation may optimize production objectives in progeny.
Keywords: Cattle; Fetal programming; IGF; Maternal nutrition; Metabolites; Postnatal growth
Rights: © 2010 Elsevier B.V. All rights reserved.
RMID: 0020098237
DOI: 10.1016/j.anireprosci.2010.05.017
Appears in Collections:Obstetrics and Gynaecology publications

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