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Type: Journal article
Title: Thrombolysis for acute stroke in Australia: outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002-2008)
Author: Simpson, M.
Dewey, H.
Churilov, L.
Ahmed, N.
Bladin, C.
Schultz, D.
Markus, R.
Sturm, J.
Levi, C.
Blacker, D.
Jannes, J.
Lindley, R.
Parsons, M.
Citation: Medical Journal of Australia, 2010; 193(8):439-443
Publisher: Australasian Med Publ Co Ltd
Issue Date: 2010
ISSN: 0025-729X
Statement of
Marion A Simpson, Helen M Dewey, Leonid Churilov, Niaz Ahmed, Christopher F Bladin, David Schultz, Romesh Markus, Jonathan W Sturm, Christopher R Levi, David J Blacker, Jim Jannes, Richard I Lindley and Mark W Parsons
Abstract: Objective: To report Australian outcomes from the Safe Implementation of Thrombolysis in Stroke International Stroke Thrombolysis Register (SITS-ISTR). Design: Observational study using data collected prospectively from December 2002 to December 2008. Setting: Centres administering thrombolysis for acute stroke in Australia and worldwide. Patients: All patients treated with recombinant tissue plasminogen activator for acute stroke in participating centres, regardless of stroke severity, time of treatment and other clinical factors. Intervention: Thrombolysis for acute stroke, administered according to local protocol. Main outcome measures: Functional outcome as 3-month modified Rankin score (mRS), and frequency of symptomatic intracerebral haemorrhage (ICH). Results: During the study period, a total of 32 countries participated, and confirmed baseline data were available for 581 Australian patients and 20 953 patients in the rest of the world. Australian patients were older (median age, 73 v 69 years; P < 0.001), were less independent before stroke (premorbid mRS of 0–1, 87.5% v 91.2%; P < 0.005), and had more comorbidities and more severe strokes. Comparing the Australian cohort with the rest of the world, the odds ratio of 3-month mRS of 0–2 was 0.98 (95% CI, 0.88–1.08; P = 0.63), the odds ratio of symptomatic ICH was 0.98 (95% CI, 0.83–1.16; P = 0.85 [by the definition used by the National Institute of Neurological Disorders]) and the odds ratio of death was 1.04 (95% CI, 0.91–1.19; P = 0.54). Good outcome in the Australian cohort was predicted by younger age, presence of hyperlipidaemia, lower premorbid mRS, absence of infarct on early brain imaging, less severe stroke, and lower baseline blood glucose level. Conclusion: Clinical outcomes after thrombolysis in Australia were similar to those worldwide.
Keywords: Humans; Acute Disease; Tissue Plasminogen Activator; Fibrinolytic Agents; Treatment Outcome; Thrombolytic Therapy; Registries; Aged; Aged, 80 and over; Middle Aged; Australia; Female; Male; Stroke
Rights: © The Medical Journal of Australia 2010
RMID: 0020101240
DOI: 10.5694/j.1326-5377.2010.tb03996.x
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