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Type: Book
Title: Beneficial effects of perhexiline in cardiovascular disease states
Author: Chirkov, Y.
Sverdlov, A.
Horowitz, J.
Publisher: NOVA Science Publishers
Issue Date: 2010
Series/Report no.: Cardiology Research and Clinical Developments
ISBN: 9781616689773
Statement of
Yuliy Y. Chirkov, Aaron L. Sverdlov, and John D. Horowitz
Abstract: Perhexiline, 2-(2,2-dicyclohexylethyl)piperidine, was originally developed as a prophylactic anti-anginal drug in the late 1960s. It was initially a popular and effective treatment for angina, having the almost unique property compared to other agents available at that time, of not inducing reductions in blood pressure or heart rate. Despite the initial success, its use diminished markedly due to the occurrence during long-term therapy of poorly understood side effects (neurotoxicity and hepatotoxicity), which later were shown to be associated with high plasma concentrations of perhexiline, occurring in patients with relatively slow hepatic metabolism of the drug. However, therapeutic plasma monitoring and associated dose adjustments have led to perhexiline's reintroduction into clinical practice. This new book discusses the benefits of perhexiline in the treatment of cardiovascular disease.
Rights: Copyright status unknown
RMID: 0030001032
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Appears in Collections:Medicine publications

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