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https://hdl.handle.net/2440/64852
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Type: | Journal article |
Title: | Correlation between pruritus score and grossly visible erythema in dogs |
Author: | Hill, P. Rybnicek, J. Lau-Gillard, P. |
Citation: | Veterinary Dermatology: an international journal, 2010; 21(5):450-455 |
Publisher: | Blackwell Science Ltd |
Issue Date: | 2010 |
ISSN: | 0959-4493 1365-3164 |
Statement of Responsibility: | Peter Hill, Jan Rybníček and Peri Lau-Gillard |
Abstract: | The severity of pruritus and the extent and severity of erythema were quantified in 107 dogs presenting with various dermatoses. Pruritus was assessed using a previously validated scale, and erythema was quantified by assessing severity at 72 different body sites. Pruritus scores were either 0, or followed a normal type of distribution, with most dogs having a score in the middle of the range and a few dogs having low or high scores. The median pruritus score was 6.3 ⁄ 10. Erythema scores were heavily skewed towards lower values, with only a few dogs having high scores. The median diffuse erythema score was 6.0 ⁄ 216 and the median score for maculo-papular ⁄ pustular erythema was 0 ⁄ 1080. Pruritus and erythema scores were significantly correlated with a Spearman rank correlation coefficient of 0.4062 (P < 0.001). However, visual assessment of the data representing the two variables revealed that this was not a consistent biological or clinically relevant correlation. Individual dogs could have a high pruritus score with low erythema score or vice versa. This study raises questions about the use of erythema scoring systems as a primary outcome measure in clinical trials, and also about the role of various inflammatory mediators in the pathogenesis of canine pruritus. |
Keywords: | Animals Dogs Erythema Pruritus Dog Diseases Pain Measurement |
Rights: | Copyright 2010 The Authors. Journal compilation Copyright 2010 ESVD and ACVD |
DOI: | 10.1111/j.1365-3164.2010.00881.x |
Published version: | http://dx.doi.org/10.1111/j.1365-3164.2010.00881.x |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest |
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