Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/65203
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Type: Journal article
Title: Antiangiogenic agents are effective inhibitors of endometriosis
Author: Hull, M.
Charnock-Jones, D.
Chan, C.
Bruner-Tran, K.
Osteen, K.
Tom, B.
Fan, T.P.
Smith, S.
Citation: The journal of Clinical Endocrinology and Metabolism, 2003; 88(6):2889-2899
Publisher: The Endocrine Society
Issue Date: 2003
ISSN: 0021-972X
1945-7197
Statement of
Responsibility: 
M. Louise Hull, D. Stephen Charnock-Jones, Clement L. K. Chan, Kaylon L. Bruner-Tran, Kevin G. Osteen, Brian D. M. Tom, Tai-Ping D. Fan, and Stephen K. Smith
Abstract: Endometriosis is a disease in which the lining of the uterus (endometrium), shed at the time of menstruation, becomes established at sites such as the peritoneum and ovaries. These explants develop a rich blood supply that enables them to survive and grow. We hypothesized that inhibitors of angiogenesis would prevent this growth by disrupting sensitive vessels supplying endometriotic lesions. Vessels sensitive to angiogenic antagonism have few associations with pericyte cells. The vessels supplying human endometriotic lesions were immunohistochemically characterized and found to be predominantly pericyte free. A model in which human endometrium is implanted into nude mice was used to test the effects of two antagonists of the angiogenic growth factor, vascular endothelial cell growth factor A. Soluble truncated receptor (flt-1; P = 0.002) and an affinity-purified antibody to human vascular endothelial cell growth factor A (P = 0.03) significantly inhibited the growth of nude mouse explants. Pericyte-free vessels were shown to supply endometrial lesions in nude mice and were disrupted in lesions taken from soluble flt-1-treated mice. In summary, antiangiogenic agents inhibited the growth of explants in an in vivo model of endometriosis by disrupting the vascular supply, and this effect is likely to apply to the human disease. These findings suggest that antiangiogenic agents may provide a novel therapeutic approach for the treatment of endometriosis.
Keywords: Endometrium; Blood Vessels; Animals; Humans; Mice; Mice, Nude; Rats; Rats, Wistar; Endometriosis; Vascular Endothelial Growth Factor Receptor-1; Angiogenesis Inhibitors; Intercellular Signaling Peptides and Proteins; Vascular Endothelial Growth Factors; Vascular Endothelial Growth Factor A; Endothelial Growth Factors; Antibodies; Lymphokines; Solubility; Female
Rights: Copyright © 2003 by The Endocrine Society
RMID: 0030001029
DOI: 10.1210/jc.2002-021912
Appears in Collections:Obstetrics and Gynaecology publications

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