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https://hdl.handle.net/2440/66474
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Type: | Journal article |
Title: | Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: A randomized controlled trial |
Author: | Smithers, L. Gibson, R. Makrides, M. |
Citation: | American Journal of Clinical Nutrition, 2011; 93(6):1293-1299 |
Publisher: | Amer Soc Clinical Nutrition |
Issue Date: | 2011 |
ISSN: | 0002-9165 1938-3207 |
Statement of Responsibility: | Lisa G Smithers, Robert A Gibson, and Maria Makrides |
Abstract: | <h4>Background</h4>The docosahexaenoic acid (DHA) intake of pregnant women is lower than estimates of the DHA accretion by the fetus, and recommendations were made to increase the DHA intake of pregnant women.<h4>Objective</h4>The objective of this study was to determine whether the supplementation of pregnant women with DHA improved the visual acuity of infants at 4 mo.<h4>Design</h4>We conducted a blinded assessment of a subset of healthy, full-term infants born to women enrolled in a double-blind, randomized controlled trial called the DHA for Maternal and Infant Outcomes (DOMInO) trial. Women were randomly assigned to consume DHA-rich fish-oil capsules (≈800 mg DHA/d in the treatment group) or vegetable oil capsules (control group) from midpregnancy to delivery. The primary outcome was the sweep visual evoked potential (VEP) acuity at 4 mo. The VEP latency at 4 mo was a secondary outcome.<h4>Results</h4>Mean (±SD) VEP acuity did not differ between treatment and control groups [treatment group: 8.37 ± 2.11 cycles per degree (cpd), n = 89; control group: 8.55 ± 1.86 cpd, n = 93; P = 0.55]. VEP latencies also did not differ between groups. Irrespective of the group, maternal smoking in pregnancy was independently associated with poorer VEP acuity in the infant.<h4>Conclusions</h4>DHA supplementation in women with singleton pregnancies does not enhance infant visual acuity in infants at 4 mo of age. Visual acuity in infancy is adversely associated with maternal smoking in pregnancy. This trial was registered at www.anzctr.org.au as ACTRN12606000327583. The DOMInO trial was registered at www.anzctr.org.au as ACTRN12605000569606. |
Keywords: | Humans Dietary Fats Docosahexaenoic Acids Fish Oils Double-Blind Method Smoking Evoked Potentials, Visual Pregnancy Visual Acuity Dietary Supplements Adult Infant Infant, Newborn Female Male Prenatal Nutritional Physiological Phenomena Young Adult |
Rights: | © 2011 American Society for Nutrition |
DOI: | 10.3945/ajcn.110.009647 |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.3945/ajcn.110.009647 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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