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https://hdl.handle.net/2440/66705
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dc.contributor.author | Rybnicek, J. | - |
dc.contributor.author | Hill, P. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Veterinary Dermatology: an international journal, 2007; 18(3):165-170 | - |
dc.identifier.issn | 0959-4493 | - |
dc.identifier.issn | 1365-3164 | - |
dc.identifier.uri | http://hdl.handle.net/2440/66705 | - |
dc.description.abstract | A case of pemphigus vulgaris (PV), putatively induced by topical application of polymyxin B ear drops, is described. A 3-year-old, female Tosa Inu, presented with acute onset swelling, blistering and ulceration of the pinnae, nostrils, lips and oral mucous membranes. The dog was depressed, febrile and anorexic. For 7 days prior to the onset of the acute ulcerative disease, polymyxin B ear drops had been applied to both ears to treat an ear infection. Skin and mucosal biopsies showed suprabasilar cleft formation and acantholysis, indicative of PV. The polymyxin B ear drops were discontinued and the dog was treated with intravenous fluids, systemic and topical antibacterial therapy, and immunosuppressive therapy comprising prednisone and azathioprine. Complete remission was noted after 2 weeks, and the immunosuppressive therapy was discontinued one month later. No clinical signs of PV recurred over a 1 year follow-up period. As PV does not usually resolve spontaneously, or enter long-term remission, it was considered that the condition was most likely drug induced due to the aural application of polymyxin B. | - |
dc.description.statementofresponsibility | Jan Rybníçek and Peter B. Hill | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Science Ltd | - |
dc.rights | © 2007 The Authors. | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1365-3164.2007.00589.x | - |
dc.subject | Ear, External | - |
dc.subject | Animals | - |
dc.subject | Dogs | - |
dc.subject | Pemphigus | - |
dc.subject | Dog Diseases | - |
dc.subject | Polymyxin B | - |
dc.subject | Anti-Bacterial Agents | - |
dc.subject | Diagnosis, Differential | - |
dc.subject | Administration, Cutaneous | - |
dc.subject | Female | - |
dc.title | Suspected polymyxin B-induced pemphigus vulgaris in a dog | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1365-3164.2007.00589.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hill, P. [0000-0002-7449-4897] | - |
Appears in Collections: | Animal and Veterinary Sciences publications Aurora harvest 5 |
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