Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/67032
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Type: Journal article
Title: The etiology of preeclampsia: The role of the father
Author: Dekker, G.
Robillard, P.
Roberts, C.
Citation: Journal of Reproductive Immunology, 2011; 89(2):126-132
Publisher: Elsevier Sci Ireland Ltd
Issue Date: 2011
ISSN: 0165-0378
1872-7603
Statement of
Responsibility: 
Gus Dekker, Pierre Yves Robillard and Claire Roberts
Abstract: Preeclampsia is often considered as simply a maternal disease with variable degrees of fetal involvement. More and more the unique immunogenetic maternal-paternal relationship is appreciated, and also the specific 'genetic conflict' that is characteristic of haemochorial placentation. From that perspective, pre-eclampsia can be seen as a disease of an individual couple with primarily maternal and fetal manifestations. The maternal and fetal genomes perform different roles during development. Heritable paternal, rather than maternal, imprinting of the genome is necessary for normal trophoblast development. Large population studies have estimated that 35% of the variance in susceptibility to preeclampsia is attributable to maternal genetic effects; 20% to fetal genetic effects (with similar contributions of both parents), 13% to the couple effect, less than 1% to the shared sibling environment and 32% to unmeasured factors. Not one of these large population studies focussed on the paternal contribution to preeclampsia, which is demonstrated by (1) the effect of the length of the sexual relationship; (2) the concept of primipaternity versus primigravidity; and (3) the existence of the so-called 'dangerous' father, as demonstrated in various large population studies. It is currently unknown how the father exerts this effect. Possible mechanisms include seminal cytokine levels and their effect on maternal immune deviation, specific paternal HLA characteristics and specific paternal single nucleotide polymorphisms (SNPs), in particular in the paternally expressed genes affecting placentation. Several large cohort studies, including the large international SCOPE consortium, have identified paternal SNPs with strong associations with preeclampsia.
Keywords: Pre-eclampsia; Paternal risk factors
Rights: Crown Copyright © 2011 Published by Elsevier Ireland Ltd. All rights reserved.
RMID: 0020111818
DOI: 10.1016/j.jri.2010.12.010
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/506024/description#description
Appears in Collections:Obstetrics and Gynaecology publications

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