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https://hdl.handle.net/2440/67180
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Type: | Journal article |
Title: | Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men |
Author: | Stewart, J. Seimon, R. Otto, B. Keast, R. Clifton, P. Feinle-Bisset, C. |
Citation: | American Journal of Clinical Nutrition, 2011; 93(4):703-711 |
Publisher: | Amer Soc Clinical Nutrition |
Issue Date: | 2011 |
ISSN: | 0002-9165 1938-3207 |
Statement of Responsibility: | Jessica E Stewart, Radhika V Seimon, Bärbel Otto, Russell SJ Keast, Peter M Clifton, and Christine Feinle-Bisset |
Abstract: | Background: Both orosensory stimulation and feedback from the gastrointestinal tract contribute to energy intake regulation. Objective: We evaluated the hypothesis that overweight or obese subjects would be less sensitive to both oral and intraduodenal oleic acid exposure than would lean subjects. Design: Eleven overweight or obese and 8 lean men were studied on 2 occasions, during which antropyloroduodenal pressures, plasma cholecystokinin and peptide YY, and appetite were measured during 90-min intraduodenal infusions of saline or oleic acid (18:1 load: 0.78 kcal/min); energy intake (buffet lunch) was determined immediately afterward. Oral detection thresholds for 18:1 and recent dietary intake (2-d recall) were also quantified. Results: In lean subjects, the number of isolated pyloric pressure waves (IPPWs) was greater during 18:1 infusion than during saline infusion (P < 0.05); no significant differences were observed between the 18:1 and saline infusions in the overweight or obese subjects. In both groups, 18:1 stimulated plasma cholecystokinin and peptide YY and suppressed energy intake compared with saline (P < 0.05), with trends for reduced cholecystokinin and energy intake responses in the overweight or obese subjects. Detection thresholds for 18:1 were greater in overweight or obese (7.9 ± 0.1 mmol/L) than in lean (4.1 ± 0.4 mmol/L) subjects (P < 0.05). Overweight or obese subjects had greater recent energy (P < 0.05) and fat (P = 0.07) intakes than did lean subjects. There was a direct relation (r = 0.669) of body mass index with 18:1 detection thresholds and inverse relations (r < −0.51) of IPPWs with body mass index and 18:1 detection thresholds (P < 0.05). Conclusions: The ability to detect oleic acid both orally and within the gastrointestinal tract is compromised in obese men, and oral and gastrointestinal responses to oleic acid are related. |
Keywords: | Duodenum Pylorus Humans Obesity Thinness Cholecystokinin Peptide YY Dietary Fats Oleic Acid Body Mass Index Sensory Thresholds Taste Energy Intake Appetite Regulation Pressure Reference Values Adult Middle Aged Male Young Adult |
Rights: | Copyright 2011 American Society for Nutrition |
DOI: | 10.3945/ajcn.110.007583 |
Published version: | http://dx.doi.org/10.3945/ajcn.110.007583 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
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