Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/67367
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Type: Journal article
Title: Discovery of lost diversity of paternal horse lineages using ancient DNA
Author: Lippold, S.
Knapp, M.
Kuznetsova, T.
Leonard, J.
Benecke, N.
Ludwig, A.
Rasmussen, M.
Cooper, A.
Weinstock, J.
Willerslev, E.
Shapiro, B.
Hofreiter, M.
Citation: Nature Communications, 2011; 2(1):1-6
Publisher: Nature Publishing Group
Issue Date: 2011
ISSN: 2041-1723
2041-1723
Statement of
Responsibility: 
Sebastian Lippold, Michael Knapp, Tatyana Kuznetsova, Jennifer A. Leonard, Norbert Benecke, Arne Ludwig, Morten Rasmussen, Alan Cooper, Jaco Weinstock, Eske Willerslev, Beth Shapiro and Michael Hofreiter
Abstract: Modern domestic horses display abundant genetic diversity within female-inherited mitochondrial DNA, but practically no sequence diversity on the male-inherited Y chromosome. Several hypotheses have been proposed to explain this discrepancy, but can only be tested through knowledge of the diversity in both the ancestral (pre-domestication) maternal and paternal lineages. As wild horses are practically extinct, ancient DNA studies offer the only means to assess this ancestral diversity. Here we show considerable ancestral diversity in ancient male horses by sequencing 4 kb of Y chromosomal DNA from eight ancient wild horses and one 2,800-year-old domesticated horse. Both ancient and modern domestic horses form a separate branch from the ancient wild horses, with the Przewalski horse at its base. Our methodology establishes the feasibility of re-sequencing long ancient nuclear DNA fragments and demonstrates the power of ancient Y chromosome DNA sequence data to provide insights into the evolutionary history of populations.
Keywords: Y Chromosome; Animals; Horses; DNA, Mitochondrial; Evolution, Molecular; Phylogeny; Molecular Sequence Data; Female; Male; Genetic Variation
Rights: © 2011 Macmillan Publishers Limited. All rights reserved.
RMID: 0020112600
DOI: 10.1038/ncomms1447
Appears in Collections:Earth and Environmental Sciences publications
Environment Institute Leaders publications

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