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Type: Journal article
Title: Epidermolysis bullosa acquisita in a great Dane
Author: Hill, P.
Boyer, P.
Lau, P.
Rybnicek, J.
Hargreaves, J.
Olivry, F.
Citation: Journal of Small Animal Practice, 2008; 49(2):89-94
Publisher: British Veterinary Assoc
Issue Date: 2008
ISSN: 0022-4510
Statement of
P. B. Hill, P. Boyer, P. Lau, J. Rybnicek, J. Hargreaves and T. Olivry
Abstract: Autoimmune subepidermal blistering diseases in dogs were all classified as bullous pemphigoid until 1998. Since then, refinements in reagents and immunological techniques have allowed diseases which are histologically similar but which have a different molecular pathogenesis to be described. This report describes the first case of one such disease, epidermolysis bullosa acquisita, to be documented in the UK. The dog presented with a severe blistering and ulcerative disease affecting the oral cavity, pinnae and distal limbs. The diagnosis was confirmed by histopathology and direct and indirect immunofluorescent demonstration of immunoglobulin G reactivity to basement membrane antigens. Treatment with glucocorticoids, azathioprine, colchicine and an intravenous infusion of immunoglobulins resulted in complete resolution. The drugs were discontinued 12 months after the start of treatment and the dog remained in remission.
Keywords: Epidermis
Epidermolysis Bullosa Acquisita
Dog Diseases
Immunoglobulin G
Immunosuppressive Agents
Fluorescent Antibody Technique
Remission Induction
Rights: © 2007 British Small Animal Veterinary Association
DOI: 10.1111/j.1748-5827.2007.00419.x
Appears in Collections:Animal and Veterinary Sciences publications
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