Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||The evaluation of a clinical scar scale for porcine burn scars|
|Citation:||Burns, 2009; 35(4):538-546|
|Publisher:||Elsevier Sci Ltd|
|Xue-Qing Wang, Olena Kravchuk, Pei-Yun Liu, Margit Kempf, Carolina V.D. Boogaard, Peter Lau, Leila Cuttle, Julie Mill and Roy M. Kimble|
|Abstract:||This study describes the evaluation of a clinical scar scale for our porcine burn scars, which includes scar cosmetic outcome, colour, height and hair, supplemented with reference porcine scar photographs representing each scar outcome and scar colour scores. A total of 72 porcine burn scars at week 6 after burn were rated in vivo and/or on photographs. Good agreements were achieved for both intra-rater reliability (correlation is 0.86-0.98) and inter-rater reliability (ICC=80-85%). The results showed statistically significant correlations for each pair in this clinical scar scale (p<0.01), with the best correlation found between scar cosmetic outcome and scar colour. A multivariate principle components analysis revealed that this clinical scar assessment was highly correlated with scar histology, wound size, and re-epithelialisation data (p<0.001). More severe scars are clinically characterised by darker purple colouration, more elevation, no presence of hair, histologically by thicker scar tissue, thinner remaining normal dermis, are more likely to have worse contraction, and slower re-epithelialisation. This study demonstrates that our clinical scar scale is a reliable, independent and valuable tool for assessing porcine burn outcome and truthfully reflects scar appearance and function. To our knowledge, this is the first study demonstrating a high correlation between clinical scar assessment and scar histology, wound contraction and re-epithelialisation data on porcine burn scars. We believe that the successful use of porcine scar scales is invaluable for assessing potential human burn treatments.|
|Keywords:||Burn injury; Clinical scar assessments; Histological scar assessments; Re-epithelialisation; Wound contraction; Wound healing|
|Rights:||Copyright 2008 Elsevier Ltd and ISBI. All rights reserved.|
|Appears in Collections:||Agriculture, Food and Wine publications|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.