Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/69087
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Type: Journal article
Title: The evaluation of a clinical scar scale for porcine burn scars
Author: Wang, X.
Kravchuk, O.
Liu, P.
Kempf, M.
Boogaard, C.
Lau, P.
Cuttle, L.
Mill, J.
Kimble, R.
Citation: Burns, 2009; 35(4):538-546
Publisher: Elsevier Sci Ltd
Issue Date: 2009
ISSN: 0305-4179
1879-1409
Statement of
Responsibility: 
Xue-Qing Wang, Olena Kravchuk, Pei-Yun Liu, Margit Kempf, Carolina V.D. Boogaard, Peter Lau, Leila Cuttle, Julie Mill and Roy M. Kimble
Abstract: This study describes the evaluation of a clinical scar scale for our porcine burn scars, which includes scar cosmetic outcome, colour, height and hair, supplemented with reference porcine scar photographs representing each scar outcome and scar colour scores. A total of 72 porcine burn scars at week 6 after burn were rated in vivo and/or on photographs. Good agreements were achieved for both intra-rater reliability (correlation is 0.86-0.98) and inter-rater reliability (ICC=80-85%). The results showed statistically significant correlations for each pair in this clinical scar scale (p<0.01), with the best correlation found between scar cosmetic outcome and scar colour. A multivariate principle components analysis revealed that this clinical scar assessment was highly correlated with scar histology, wound size, and re-epithelialisation data (p<0.001). More severe scars are clinically characterised by darker purple colouration, more elevation, no presence of hair, histologically by thicker scar tissue, thinner remaining normal dermis, are more likely to have worse contraction, and slower re-epithelialisation. This study demonstrates that our clinical scar scale is a reliable, independent and valuable tool for assessing porcine burn outcome and truthfully reflects scar appearance and function. To our knowledge, this is the first study demonstrating a high correlation between clinical scar assessment and scar histology, wound contraction and re-epithelialisation data on porcine burn scars. We believe that the successful use of porcine scar scales is invaluable for assessing potential human burn treatments.
Keywords: Burn injury; Clinical scar assessments; Histological scar assessments; Re-epithelialisation; Wound contraction; Wound healing
Rights: Copyright 2008 Elsevier Ltd and ISBI. All rights reserved.
RMID: 0020114341
DOI: 10.1016/j.burns.2008.10.005
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/30394/description#description
Appears in Collections:Agriculture, Food and Wine publications

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