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Type: Journal article
Title: Association of vascular endothelial growth factor +936 C/T single-nucleotide polymorphism with pregnancies complicated by small-for-gestational-age babies
Author: Andraweera, P.
Dekker, G.
Thompson, S.
Nowak, R.
Zhang, V.
McCowan, L.
North, R.
Roberts, C.
Citation: Archives of Pediatrics & Adolescent Medicine, 2011; 165(12):1123-1130
Publisher: Amer Medical Assoc
Issue Date: 2011
ISSN: 1072-4710
Statement of
Prabha H. Andraweera, Gustaaf A. Dekker, Steven D. Thompson, Rachael C. Nowak, Jamie V. Zhang, Lesley M. E. McCowan, Robyn A. North, Claire T. Roberts
Abstract: Objectives: To examine whether single-nucleotide polymorphisms (SNPs) in VEGFA (–2578 C/A and +936 C/T) associate with small-for-gestational-age (SGA) pregnancies and to identify their effects on first-trimester placental VEGFA expression. Design: Multicenter prospective cohort study. Settings Adelaide, Australia, and Auckland, New Zealand. Participants: A total of 3234 nulliparous pregnant women, their partners, and their infants. Main Outcome Measures: The SNPs in the parent-infant trios and first-trimester placentae (n = 74) were genotyped. Placental VEGFA messenger RNA expression was determined by quantitative reverse transcription–polymerase chain reaction. Small for gestational age was defined as a birth weight less than the 10th customized birth weight percentile adjusted for maternal height, weight, parity, and ethnicity and for gestational age at delivery and infant sex. Uterine and umbilical artery Doppler was performed at 20 weeks' gestation, and resistance indices greater than the 90th percentile were considered abnormal. Results: Of 2123 pregnancies, 1176 (55.4%) were uncomplicated and 216 (10.2%) had SGA infants. Neonatal VEGFA +936 C/T SNP associates with SGA (adjusted odds ratio [aOR], 1.6; 95% CI, 1.0-2.3), SGA with abnormal Doppler findings (aOR, 3.5; 95% CI, 1.8-7.1), lower birth weight (P = .006), customized birth weight percentile (P = .049), and abnormal uterine artery Doppler findings (OR, 2.5; 95% CI, 1.2-5.4). Maternal VEGFA +936 C/T associates with abnormal umbilical artery Doppler findings (OR, 1.5; 95% CI, 1.1-2.2). VEGFA +936 CT+TT first-trimester placentae have 36% lower VEGFA messenger RNA expression compared with CC (P = .045). Conclusion: Neonatal VEGFA +936 C/T associates with SGA, and the association is stronger for SGA with abnormal uterine or umbilical artery Doppler findings. The SNP also associates with reduced first-trimester placental VEGFA expression, suggesting that it may have a role in the pathogenesis of SGA.
Keywords: Umbilical Arteries; Humans; Pregnancy Complications; Pre-Eclampsia; Vascular Endothelial Growth Factor C; RNA, Messenger; Ultrasonography, Doppler; Ultrasonography, Prenatal; Logistic Models; Risk Factors; Chi-Square Distribution; Case-Control Studies; Prospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Pregnancy; Pregnancy Trimester, First; Genotype; Polymorphism, Single Nucleotide; Adult; Infant, Newborn; Infant, Small for Gestational Age; Australia; New Zealand; Female; Uterine Artery
Rights: ©2011 American Medical Association. All rights reserved.
RMID: 0020115176
DOI: 10.1001/archpediatrics.2011.796
Appears in Collections:Obstetrics and Gynaecology publications

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