Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/6950
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Type: Journal article
Title: The FMR2 gene, FRAXE and non-specific X-linked mental retardation: clinical and molecular aspects
Author: Gecz, J.
Citation: Annals of Human Genetics, 2000; 64(2):95-106
Publisher: Blackwell Publishing Ltd
Issue Date: 2000
ISSN: 0003-4800
1469-1809
Abstract: FRAXE fragile site associated mental retardation remains unique among X-linked mental retardation phenotypes due to its very mild to borderline nature (50< IQ< 85). It is the most prevalent form of non-specific X-linked mental retardation so far delineated, with an estimated incidence of at least 1/50-100,000 males, and with more than 50 families known worldwide. The FRAXE site is within, or immediately adjacent to, the 5' untranslated region of the FMR2 gene. Hyperexpansion of the FRAXE CCG repeat silences transcription of the gene. The structure of FMR2 has been characterized, but its function remains unknown. Gene localizations for numerous (> 75) large families with non-specific X-linked mental retardation (MRX) have been determined so far. Recently the molecular basis for some of them has been unravelled by identification of the responsible genes, which participate in complex common signalling pathways. This review summarises the new data on FRAXE associated mental retardation and the FMR2 gene in the light of the recent discoveries of new genes responsible for other forms of non-specific X-linked mental retardation.
Keywords: X Chromosome; Humans; Fragile X Syndrome; Chromosome Fragility; Proteins; Trans-Activators; Nuclear Proteins; Phenotype; Mutation; Chromosome Fragile Sites; Male; Genetic Testing; Genetic Linkage; Intellectual Disability
RMID: 0001000262
DOI: 10.1017/S0003480000007983
Appears in Collections:Paediatrics publications

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