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|Title:||Conservative surgical debridement as a burn treatment: supporting evidence from a porcine burn model|
|Citation:||Wound Repair and Regeneration, 2008; 16(6):774-783|
|Publisher:||Blackwell Publishing Inc|
|Xue-Qing Wang, Margit Kempf, Pei-Yun Liu, Leila Cuttle, Hong-En Chang, Olena Kravchuk, Julie Mill, Gael E Phillips, Roy M. Kimble|
|Abstract:||In thermal deep-dermal burns, surgical debridement is normally used in conjunction with skin grafting or skin substitutes and debridement alone as a burn treatment is not usually practiced. The current study addresses whether or not debridement alone would enhance burn wound healing on small deep-dermal-partial thickness burns. This was a prospective and blinded experimental trial using a porcine deep-dermal-partial thickness burn model. Four burns, approximately 50 cm2 in size, were created on each of eight pigs. Two burns from each pig were immediately surgically debrided and the other two were not debrided as the internal control. Hydrate gel together with paraffin gauze were used to cover the burns for four pigs and silver dressings for the other four. Clinical assessment of wound healing was conducted over a 6-week period. Skin samples were collected at the end of the experiment and histopathological evaluation was performed. The results show thinner scar formation and lower scar height in the debrided compared with nondebrided wounds in the hydrate gel/paraffin gauze groups. There were no statistically significant differences in wound healing assessment between the debrided and nondebrided wounds dressed with silver dressings. This study provides supporting evidence that immediate debridement with an appropriate dressing and without skin grafting may promote wound healing, suggesting its potential benefit for clinical patients.|
|Keywords:||Animals; Swine; Burns; Disease Models, Animal; Debridement; Bandages; Female|
|Rights:||© 2008 by the Wound Healing Society|
|Appears in Collections:||Agriculture, Food and Wine publications|
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