Adelaide Research & Scholarship
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https://hdl.handle.net/2440/7026
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| Type: | Journal article |
| Title: | Cloning and sequence analysis of caprine N-acetylglucosamine 6-sulfatase cDNA |
| Author: | Friderici, K. Cavanagh, K. Leipprandt, J. Traviss, C. Anson, D. Hopwood, J. Jones, M. |
| Citation: | Biochimica et Biophysica Acta: international journal of biochemistry and biophysics, 1995; 1271(2-3):369-373 |
| Publisher: | Elsevier/North Holland |
| Issue Date: | 1995 |
| ISSN: | 0006-3002 1878-2434 |
| Abstract: | Mucopolysaccharidosis IIID results from the deficiency of N-acetylglucosamine 6-sulfatase activity. A Nubian goat with this lysosomal storage disease has been identified. As a first step in developing this animal model for testing treatment methods, we cloned and sequenced the caprine N-acetylglucosamine 6-sulfatase cDNA coding region. Overall there is 88% nucleotide homology between the goat and human sequence and 94% homology of the deduced amino acid sequence. The human and two ruminant species differ by the presence of an imperfect trinucleotide (CCG) repeat in the ruminant signal sequence. |
| Keywords: | Animals Goats Mucopolysaccharidosis III Sulfatases DNA, Complementary Cloning, Molecular Amino Acid Sequence Base Sequence Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Molecular Sequence Data |
| DOI: | 10.1016/0925-4439(95)00054-8 |
| Published version: | http://dx.doi.org/10.1016/0925-4439(95)00054-8 |
| Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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