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https://hdl.handle.net/2440/7043
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Type: | Journal article |
Title: | Results of consecutive trials for children newly diagnosed with acute myeloid leukemia from the Australian and New Zealand Children's Cancer Study Group |
Author: | O'Brien, T. Russell, S. Vowels, M. Oswald, C. Tiedemann, K. Shaw, P. Lockwood, L. Teague, L. Rice, M. Marshall, G. |
Citation: | Blood, 2002; 100(8):2708-2716 |
Publisher: | Amer Soc Hematology |
Issue Date: | 2002 |
ISSN: | 0006-4971 1528-0020 |
Statement of Responsibility: | Tracey A. O'Brien, Susan J. Russell, Marcus R. Vowels, Cecilia M. Oswald, Karin Tiedemann, Peter J. Shaw, Liane Lockwood, Lochie Teague, Michael Rice and Glenn M. Marshall |
Abstract: | Despite improvements in the treatment of acute myeloid leukemia (AML), approximately 50% of children die of the disease. Clinical trials in adult patients with AML indicate that idarubicin may have superior efficacy when compared to daunorubicin in the remission-induction phases of chemotherapy. We conducted consecutive clinical trials in children with newly diagnosed AML in which daunorubicin (group 1, n = 102) or idarubicin (group 2, n = 160) was used during the remission-induction (RI) and the early consolidation phases of chemotherapy. Idarubicin was given at a dose of either 10 mg/m2 (group 2A, n = 106) or 12 mg/m2 (group 2B, n = 53). A high rate of RI was achieved for all groups (95% group 1, 90% group 2A, 94% group 2B). There were no significant differences in 5-year event-free survival (EFS) or in overall survival (OS) when the 3 groups were compared (group 1: EFS 50%, OS 56%; group 2A: EFS 50%, OS 60%; group 2B: EFS 34%, OS 50%). RI deaths resulting from treatment toxicity were low---2% for group 1 and 5% for group 2. More gastrointestinal, pulmonary, and renal toxicity but fewer infections were observed in patients receiving idarubicin (P < .001, P = .04, P = .03, respectively). Following RI chemotherapy, all patients received 3 to 4 more courses of identical chemotherapy and then underwent either autologous (n = 156) or an allogeneic bone marrow transplantation (BMT) (n = 35). OS was higher in allogeneic BMT patients than in autologous BMT patients (79% vs 63%; P = .23). We conclude that daunorubicin is as effective as idarubicin for remission-induction therapy for childhood AML and has reduced toxicity. |
Keywords: | Australian and New Zealand Children's Cancer Study Group Humans Recurrence Daunorubicin Idarubicin Antibiotics, Antineoplastic Antineoplastic Combined Chemotherapy Protocols Disease-Free Survival Treatment Outcome Remission Induction Bone Marrow Transplantation Survival Analysis Time Factors Adolescent Child Child, Preschool Infant Australia New Zealand Leukemia, Myeloid, Acute |
Rights: | © 2002 by The American Society of Hematology. |
DOI: | 10.1182/blood.V100.8.2708 |
Published version: | http://bloodjournal.hematologylibrary.org/cgi/content/abstract/100/8/2708 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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