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https://hdl.handle.net/2440/70606
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Type: | Journal article |
Title: | Suppressor of cytokine signaling 4 (SOCS4): moderator of ovarian primordial follicle activation |
Author: | Sutherland, J. Keightley, R. Nixon, B. Roman, S. Robker, R. Russell, D. McLaughlin, E. |
Citation: | Journal of Cellular Physiology, 2012; 227(3):1188-1198 |
Publisher: | Wiley Online Library |
Issue Date: | 2012 |
ISSN: | 0021-9541 1097-4652 |
Statement of Responsibility: | J.M. Sutherland, R.A. Keightley, B. Nixon, S.D. Roman, R.L. Robker, D.L. Russell and E.A. McLaughlin |
Abstract: | Mammalian ovarian primordial follicle activation and regulation is considered as one of the most important stages of folliculogenesis and as such requires exquisite control. Selection of quiescent follicles to enter the growing pool determines the rate of supply of maturing follicles over the female reproductive lifespan. To coordinate this process a range of positive and negative input signals contribute to determine follicle fate. This study demonstrates that the cytokine Leukemia Inhibitory Factor (LIF) activates the Janus Kinase 1/Signal Transducers and Activators of Transcription 3 (JAK1/STAT3) signaling pathway in pre‐granulosa cells and positively regulates primordial follicle activation. Negative regulation of the JAK/STAT pathway is controlled by the suppressor of cytokine signaling 4 (SOCS4) protein, which target members of negative feedback loops, Cardiotrophin like Cytokine (CLC), Poly (rC) Binding Protein 1 (PCBP1), and Cytosolic Malate Dehydrogenase (MDH1) to suppress follicle growth and development. |
Keywords: | Ovarian Follicle Cell Line Animals Animals, Outbred Strains Mice Recombinant Fusion Proteins Organ Culture Techniques Signal Transduction Female Suppressor of Cytokine Signaling Proteins Primary Cell Culture |
Rights: | Copyright © 2011 Wiley Periodicals, Inc. |
DOI: | 10.1002/jcp.22837 |
Grant ID: | http://purl.org/au-research/grants/arc/DP0878355 |
Published version: | http://dx.doi.org/10.1002/jcp.22837 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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