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https://hdl.handle.net/2440/7064
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DC Field | Value | Language |
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dc.contributor.author | Han, P. | - |
dc.contributor.author | Hodge, G. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | British Journal of Haematology, 1999; 107(2):450-457 | - |
dc.identifier.issn | 0007-1048 | - |
dc.identifier.issn | 1365-2141 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7064 | - |
dc.description.abstract | A 'cytokine storm' consisting of IL-1, IL-2, IL-12, IFNgamma and TNFalpha is considered important in the development of graft-versus-host disease (GvHD). These cytokines activate effector cells or damage host tissues. Cord blood transplantation has been associated with a low incidence of GvHD. We hypothesized that the low incidence of GvHD relates to the cord mononuclear cells being poor producers of pro-inflammatory cytokines. The cytokine profile (IL-1alpha/beta, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IFNgamma and TNFalpha) of cord blood cells induced by immune stimuli was determined in heparinized whole blood. Compared to adult, cord blood CD3+ and NK cells produced less IFNgamma, less cord blood CD3+ cells and monocytes produced TNFalpha and less monocytes produced IL-1alpha/beta. Although more cord T cells produced IL-2 compared to adult T cells at 4 h, adult T cells produced more at 24 h. Cord blood had similar proportions of monocytes to adult producing IL-6, IL-10 and IL-12. Both adult and cord mononuclear cells constitutively expressed receptors for IFNgamma and TNFalpha but not IL-12. In contrast to the adult cells, cord CD3+ and NK cells did not express IL-12 receptor but did up-regulate IL-10 receptor after mitogenic stimulation. The findings of this study indicate that the cord blood cytokine-receptor network is biased towards anti-inflammatory activity compared to adult and helps to explain the decreased incidence of GVHD in cord blood transplantation. | - |
dc.description.statementofresponsibility | Han, P. ; Hodge, G | - |
dc.language.iso | en | - |
dc.publisher | Wiley | - |
dc.source.uri | http://dx.doi.org/10.1046/j.1365-2141.1999.01696.x | - |
dc.subject | cord mononuclear cells | - |
dc.subject | cytokine and receptor network | - |
dc.subject | cord blood transplantation | - |
dc.title | Intracellular cytokine production and cytokine receptor interaction of cord mononuclear cells: relevance to cord blood transplantation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1046/j.1365-2141.1999.01696.x | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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