Adelaide Research & Scholarship
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https://hdl.handle.net/2440/7156
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| Type: | Journal article |
| Title: | The molecular basis of fragile sites in human chromosomes |
| Author: | Sutherland, G. Richards, R. |
| Citation: | Current Opinion in Genetics and Development, 1995; 5(3):323-327 |
| Publisher: | Current Biology Ltd. |
| Issue Date: | 1995 |
| ISSN: | 0959-437X 1879-0380 |
| Statement of Responsibility: | Grant R. Sutherland and Robert I. Richards |
| Abstract: | Fragile sites on chromosomes have been classified into a number of groups according to their frequency and the conditions required to induce them. A number of the rare folate-sensitive fragile sites have been characterized and shown to be amplified methylated CCG trinucleotide repeats. One common fragile site has been partly characterized and appears to be a region of fragility, rather than a single site. |
| Keywords: | Chromosomes, Human Humans Chromosome Fragility Aphidicolin Culture Techniques Sequence Analysis, DNA Gene Expression Regulation Repetitive Sequences, Nucleic Acid Mutation Genes Chromosome Fragile Sites |
| DOI: | 10.1016/0959-437X(95)80046-8 |
| Published version: | http://dx.doi.org/10.1016/0959-437x(95)80046-8 |
| Appears in Collections: | Aurora harvest Paediatrics publications |
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