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Type: Journal article
Title: Progression of borderline increases in albuminuria in adolescents with insulin-dependent Diabetes Mellitus
Author: Couper, J.
Clarke, C.
Byrne, G.
Jones, T.
Donaghue, K.
Nairn, J.
Boyce, D.
Russell, M.
Stephens, M.
Raymond, J.
Bates, D.
McCaul, K.
Citation: Diabetic Medicine, 1997; 14(9):766-771
Publisher: WILEY
Issue Date: 1997
ISSN: 0742-3071
Abstract: We aimed to determine the natural history of borderline increases in albuminuria in adolescents with insulin-dependent (Type 1) diabetes mellitus (IDDM) and factors which are associated with progression to persistent microalbuminura. Fifty-five normotensive adolescents with IDDM and intermittent microalbuminura (overnight albumin excretion ratte of 20-200 micrograms min-1 on one of three consecutive timed collections, n = 29) or borderline albuminura (mean overnight albumin excretion rate of 7.2-20 micrograms min-1 on one of three consecutive timed collections, n = 30) were followed prospectively at 3 monthly intervals. The endpoint was persistent microalbuminuria defined as a minimum of three of four consecutive overnight albumin excretion rates of greater than 20 micrograms min-1. One hundred and forty-two adolescents with IDDM and normoalbuminura were also followed prospectively. Fifteen of the 59 patients (25.4%) with intermittent (9/29) or borderline (6/30) albuminura progressed to persistent microalbuminura (progressors) over 28 (15-50) months [median (range)] in comparison with two of the 142 patients with normoalbuminuria at entry (relative risk = 12.6; p = 0.001). Progressors to persistent microalbuminura were pubertal and had higher systolic (p = 0.02) and diastolic (p = 0.02) blood pressure, and HbA1c (p = 0.004) than non-progressors. All patients remained normotensive. Glomerular filtration rate, apolipoproteins, dietary phosphorus, protein and sodium intakes, and prevalence of smoking did not differ between progressors and non-progressors. Total renin was higher in the diabetic patients without a difference between progressors and non-progressors. In conclusion there is a relatively high rate of progression to persistent microalbuminuria in pubertal adolescents with borderline increases in albuminura and duration greater than 3 years. These patients require attention to minimize associated factors of poor metabolic control and higher blood pressure in the development of incipient nephropathy.
Keywords: Humans; Diabetic Nephropathies; Albuminuria; Diabetes Mellitus, Type 1; Disease Progression; Serum Albumin; Follow-Up Studies; Prospective Studies; Blood Pressure; Time Factors; Adolescent; Child; Female; Male; Glycated Hemoglobin A
RMID: 0030005670
DOI: 10.1002/(SICI)1096-9136(199709)14:9<766::AID-DIA467>3.0.CO;2-X
Appears in Collections:Paediatrics publications

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