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Type: Journal article
Title: Substrate specificity of rat liver mitochondrial carnitine palmitoyl transferase I : Evidence against a-oxidation of phytanic acid in rat liver mitochondria
Author: Singh, H.
Poulos, A.
Citation: FEBS Letters, 1995; 359(2-3):179-183
Publisher: Elsevier
Issue Date: 1995
ISSN: 0014-5793
Abstract: The two branched chain fatty acids pristanic acid (2,6,10,14-tetramethylpentadecanoic acid) and phytanic acid (3,7,11,15-tetramethylhexadecanoic acid) were converted to co-enzyme A thioesters by rat liver mitochondrial outer membranes. However, these branched chain fatty acids could not be converted to pristanoyl and phytanoyl carnitines, respectively, by mitochondrial outer membranes. As expected, the unbranched long chain fatty acids, stearic acid and palmitic acid, were rapidly converted to stearoyl and palmitoyl carnitines, respectively, by mitochondrial outer membranes. These observations indicate that the branched chain fatty acids could not be transported into mitochondria. The data presented strongly suggest that in rat liver, alpha-oxidation of phytanic acid occurs in organelles other than mitochondria.
Keywords: Intracellular Membranes
Mitochondria, Liver
Phytanic Acid
Coenzyme A
Coenzyme A Ligases
Carnitine O-Palmitoyltransferase
Fatty Acids
Saccharomyces cerevisiae Proteins
Repressor Proteins
Substrate Specificity
Biological Transport
In Vitro Techniques
DOI: 10.1016/0014-5793(95)00035-8
Appears in Collections:Aurora harvest
Paediatrics publications

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