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Type: Journal article
Title: Molecular cloning and chromosomal mapping of the human homologue of MYB binding protein (P160) 1A (MYBBP1A) to 17p13.3
Author: Keough, R.
Woollatt, E.
Crawford, J.
Sutherland, G.
Plummer, S.
Casey, G.
Gonda, T.
Citation: Genomics, 1999; 62(3):483-489
Issue Date: 1999
ISSN: 0888-7543
Abstract: We have previously isolated and characterized murine MYB binding protein (p160) 1a, a protein that specifically interacts with the leucine zipper motif within the negative regulatory domain of the c-Myb proto-oncoprotein. We now describe the molecular cloning of the human MYBBP1A cDNA and chromosomal localization to 17p13.3 by fluorescence in situ hybridization analysis. Given the likely presence of a tumor suppressor gene (or genes) within this region of chromosome 17, the position of MYBBP1A was further mapped by radiation hybrid analysis and was found to lie between markers D17S1828 and D17S938. A P1 artificial chromosome clone containing the 5' region of MYBBP1A was isolated and indicates a physical linkage between MYBBP1A and the 15-lipoxygenase gene (ALOX15). A novel, polymorphic (CA)(25) dinucleotide repeat was also isolated from this PAC and may serve as a useful marker for MYBBP1A and this region of chromosome 17.
Keywords: Chromosomes, Human, Pair 17; Humans; Carrier Proteins; Nucleocytoplasmic Transport Proteins; Nuclear Proteins; Genetic Markers; Blotting, Northern; In Situ Hybridization, Fluorescence; Physical Chromosome Mapping; Cloning, Molecular; Sequence Analysis, DNA; Organ Specificity; Amino Acid Sequence; Base Sequence; Dinucleotide Repeats; Sequence Homology, Amino Acid; Alleles; Molecular Sequence Data; Terminology as Topic
Rights: Copyright © 1999 Academic Press. All rights reserved.
RMID: 0030005639
DOI: 10.1006/geno.1999.6035
Appears in Collections:Paediatrics publications

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