Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/72963
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dc.contributor.authorSoo, P.en
dc.contributor.authorHiscock, J.en
dc.contributor.authorBotting, K.en
dc.contributor.authorRoberts, C.en
dc.contributor.authorDavey, A.en
dc.contributor.authorMorrison, J.en
dc.date.issued2012en
dc.identifier.citationReproductive Toxicology, 2012; 33(3):374-381en
dc.identifier.issn0890-6238en
dc.identifier.issn1873-1708en
dc.identifier.urihttp://hdl.handle.net/2440/72963-
dc.description.abstractPoor nutrition is a major cause of fetal growth restriction which increases neonatal morbidity and mortality, as well as the risk of adult onset diseases. The objective of the study was to determine the effect of maternal undernutrition on P-glycoprotein (P-gp) expression in the placenta and the brain of both the mother and the fetus. Maternal undernutrition in guinea pigs caused placental restriction, and thus decreased fetal weight. Pups in the maternal undernutrition (UN) group had fewer capillaries in the placenta and more capillaries in the brain of the fetus. Placental, maternal and fetal brain MDR1 mRNA expression was the same in the Control and UN groups. Maternal undernutrition resulted in a significant decrease in P-gp protein expression in the placenta and fetal brain, but not the maternal brain. These findings indicate that maternal undernutrition may impact on fetal exposure to drugs administered to the mother during pregnancy due to changes in placental transfer.en
dc.description.statementofresponsibilityPoh S. Soo, Jennifer Hiscock, Kimberley J. Botting, Claire T. Roberts, Andrew K. Davey and Janna L. Morrisonen
dc.language.isoenen
dc.publisherPergamon-Elsevier Science Ltden
dc.rights© 2012 Elsevier Inc. All rights reserveden
dc.subjectBlood-Brain Barrier; Brain; Placenta; Animals; Guinea Pigs; Fetal Growth Retardation; Malnutrition; P-Glycoprotein; RNA, Messenger; Organ Size; Gestational Age; Pregnancy; Femaleen
dc.titleMaternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestationen
dc.typeJournal articleen
dc.identifier.rmid0020118352en
dc.identifier.doi10.1016/j.reprotox.2012.01.013en
dc.identifier.pubid24889-
pubs.library.collectionObstetrics and Gynaecology publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRoberts, C. [0000-0002-9250-2192]en
Appears in Collections:Obstetrics and Gynaecology publications

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