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Type: Journal article
Title: Integration of transcript and genetic maps of chromosome 16 at near-1-Mb resolution: demonstration of a 'hot-spot' for recombination at 16p12
Author: Callen, D.
Lane, S.
Kozman, H.
Kremmidiotis, G.
Whitmore, S.
Lowenstein, M.
Doggett, N.
Kenmochi, N.
Page, D.
Maglott, D.
Nierman, W.
Murakawa, K.
Sikela, J.
Houlgatte, R.
Auffray, C.
Sutherland, G.
Citation: Genomics, 1995; 29(2):503-511
Publisher: Academic Press
Issue Date: 1995
ISSN: 0888-7543
Abstract: A single mapping resource, a mouse/human somatic cell panel with average distance between breakpoints of 1.2 Mb and a potential resolution of 1 Mb, has been utilized to integrate the genetic map and a transcript map of human chromosome 16. This map includes 141 genetic markers and 200 genes and transcripts. The localization of four genes (CHEL3, TK2, TRG1, and MMP9) reported to map to chromosome 16 could not be confirmed, and for three of these localizations to other human chromosomes are reported. A correlation between genetic and physical distance over a region estimated to be 23 Mb on the short arm of chromosome 16 identified an interval demonstrating a greatly increased rate of recombination where, in females, 1 cM is equivalent to a physical distance of 100 kb.
Keywords: Hybrid Cells
Chromosomes, Human, Pair 16
Chromosome Deletion
DNA Primers
Genetic Markers
Cell Fusion
Chromosome Mapping
Polymerase Chain Reaction
Human Genome Project
Transcription, Genetic
Recombination, Genetic
Base Sequence
Molecular Sequence Data
Databases, Factual
DOI: 10.1006/geno.1995.9005
Appears in Collections:Aurora harvest 5
Paediatrics publications

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