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Type: Journal article
Title: Low copy number of the FCGR3B gene and rheumatoid arthritis: a case-control study and meta-analysis
Author: Graf, S.
Lester, S.
Nossent, J.
Hill, C.
Proudman, S.
Lee, A.
Rischmueller, M.
Citation: Arthritis Research and Therapy, 2012; 14(1):1-7
Publisher: BioMed Central Ltd.
Issue Date: 2012
ISSN: 1478-6354
Statement of
Scott W Graf, Sue Lester, Johannes C Nossent, Catherine L Hill, Susanna M Proudman, Anita Lee and Maureen Rischmueller
Abstract: Introduction: Low copy number (CN) of the Fc gamma receptor 3B (FCGR3B) gene has been associated with systemic autoimmune disease. This receptor for IgG is present almost exclusively on neutrophils and plays a role in their interaction with immune complexes. At present the relationship between FCGR3B and rheumatoid arthritis (RA) is unclear. The aim of the present study was to investigate whether low CN of the FCGR3B gene is associated with susceptibility to RA. Method: The FCGR3B CN was determined using a custom Taqman® CN assay (Hs04211858; Applied Biosystems, Foster City, CA, USA) in 197 RA patients, recruited from a tertiary setting, and in 162 population matched controls. Odds ratios for low CN (< 2) and high CN (> 2), both relative to the normal diploid 2CN, were estimated by logistic regression. Results: A significant association between RA and low FCGR3B CN was observed, with frequencies of 13.7% in RA patients compared with 6.2% in controls (odds ratio 2.5, 95% confidence interval 1.2 to 5.4, P = 0.017). No association was observed between low CN and the presence of rheumatoid factor, anti-cyclic citrullinated peptide antibodies or radiographic erosions in RA patients. A meta-analysis including six previous studies confirmed an association between RA and low FCGR3B CN (odds ratio 1.47, 95% confidence interval 1.13 to 1.92, P = 0.004). Conclusions: The present study confirms that a low CN of the FCGR3B gene is associated with susceptibility to RA. The association may be stronger in patients recruited from a tertiary setting, which may relate to disease severity and/or complications. The mechanism of susceptibility remains unclear and further study is required.
Keywords: Humans
Arthritis, Rheumatoid
Genetic Predisposition to Disease
Receptors, IgG
Logistic Models
Case-Control Studies
Polymerase Chain Reaction
Gene Dosage
Middle Aged
DNA Copy Number Variations
GPI-Linked Proteins
Tertiary Care Centers
Rights: © 2012 Graf et al.; licensee BioMed Central Ltd.This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: 10.1186/ar3731
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