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Type: Journal article
Title: Familial focal epilepsy with variable foci mapped to chromosome 22q12: Expansion of the phenotypic spectrum
Author: Klein, K.
O'Brien, T.
Praveen, K.
Heron, S.
Mulley, J.
Foote, S.
Berkovic, S.
Scheffer, I.
Citation: Epilepsia, 2012; 53(8):151-155
Publisher: Blackwell Publishing Inc
Issue Date: 2012
ISSN: 0013-9580
Statement of
Karl Martin Klein, Terence J. O'Brien, Kavita Praveen, Sarah E. Heron, John C. Mulley, Simon Foote, Samuel F. Berkovic, and Ingrid E. Scheffer
Abstract: We aimed to refine the phenotypic spectrum and map the causative gene in two families with familial focal epilepsy with variable foci (FFEVF). A new five-generation Australian FFEVF family (A) underwent electroclinical phenotyping, and the original four-generation Australian FFEVF family (B) (Ann Neurol, 44, 1998, 890) was re-analyzed, including new affected individuals. Mapping studies examined segregation at the chromosome 22q12 FFEVF region. In family B, the original whole genome microsatellite data was reviewed. Five subjects in family A and 10 in family B had FFEVF with predominantly awake attacks and active EEG studies with a different phenotypic picture from other families. In family B, reanalysis excluded the tentative 2q locus reported. Both families mapped to chromosome 22q12. Our results confirm chromosome 22q12 as the solitary locus for FFEVF. Both families show a subtly different phenotype to other published families extending the clinical spectrum of FFEVF.
Keywords: Chromosome 22q12
Focal epilepsy
Genetic epilepsy.
Rights: Wiley Periodicals, Inc. © 2012 International League Against Epilepsy
DOI: 10.1111/j.1528-1167.2012.03585.x
Appears in Collections:Aurora harvest
Paediatrics publications

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