Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/73553
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Type: | Journal article |
Title: | The Oncogenic role of miR-155 in breast cancer |
Author: | Mattiske, S. Suetani, R. Neilsen, P. Callen, D. |
Citation: | Cancer Epidemiology, Biomarkers and Prevention, 2012; 21(8):1236-1243 |
Publisher: | American Association for Cancer Research |
Issue Date: | 2012 |
ISSN: | 1055-9965 1538-7755 |
Statement of Responsibility: | Sam Mattiske, Rachel J. Suetani, Paul M. Neilsen, and David F. Callen |
Abstract: | miR-155 is an oncogenic miRNA with well described roles in leukemia. However, additional roles of miR-155 in breast cancer progression have recently been described. A thorough literature search was conducted to review all published data to date, examining the role of miR-155 in breast cancer. Data on all validated miR-155 target genes was collated to identify biologic pathways relevant to miR-155 and breast cancer progression. Publications describing the clinical relevance, functional characterization, and regulation of expression of miR-155 in the context of breast cancer are reviewed. A total of 147 validated miR-155 target genes were identified from the literature. Pathway analysis of these genes identified likely roles in apoptosis, differentiation, angiogenesis, proliferation, and epithelial-mesenchymal transition. The large number of validated miR-155 targets presented here provide many avenues of interest as to the clinical potential of miR-155. Further investigation of these target genes will be required to elucidate the specific mechanisms and functions of miR-155 in breast cancer. This is the first review examining the role of miR-155 in breast cancer progression. The collated data of target genes and biologic pathways of miR-155 identified in this review suggest new avenues of research for this oncogenic miRNA. |
Keywords: | Cell Line, Tumor Animals Humans Breast Neoplasms MicroRNAs Cell Proliferation Gene Expression Regulation, Neoplastic Female |
Rights: | © 2012 American Association for Cancer Research |
DOI: | 10.1158/1055-9965.EPI-12-0173 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/1009447 |
Published version: | http://dx.doi.org/10.1158/1055-9965.epi-12-0173 |
Appears in Collections: | Aurora harvest 5 Medicine publications |
Files in This Item:
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hdl_73553.pdf | Accepted version | 523.21 kB | Adobe PDF | View/Open |
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