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Type: Journal article
Title: The Oncogenic role of miR-155 in breast cancer
Author: Mattiske, S.
Suetani, R.
Neilsen, P.
Callen, D.
Citation: Cancer Epidemiology Biomarkers & Prevention, 2012; 21(8):1236-1243
Publisher: Amer Assoc Cancer Research
Issue Date: 2012
ISSN: 1055-9965
Statement of
Sam Mattiske, Rachel J. Suetani, Paul M. Neilsen, and David F. Callen
Abstract: miR-155 is an oncogenic miRNA with well described roles in leukemia. However, additional roles of miR-155 in breast cancer progression have recently been described. A thorough literature search was conducted to review all published data to date, examining the role of miR-155 in breast cancer. Data on all validated miR-155 target genes was collated to identify biologic pathways relevant to miR-155 and breast cancer progression. Publications describing the clinical relevance, functional characterization, and regulation of expression of miR-155 in the context of breast cancer are reviewed. A total of 147 validated miR-155 target genes were identified from the literature. Pathway analysis of these genes identified likely roles in apoptosis, differentiation, angiogenesis, proliferation, and epithelial-mesenchymal transition. The large number of validated miR-155 targets presented here provide many avenues of interest as to the clinical potential of miR-155. Further investigation of these target genes will be required to elucidate the specific mechanisms and functions of miR-155 in breast cancer. This is the first review examining the role of miR-155 in breast cancer progression. The collated data of target genes and biologic pathways of miR-155 identified in this review suggest new avenues of research for this oncogenic miRNA.
Keywords: Cell Line, Tumor; Animals; Humans; Breast Neoplasms; MicroRNAs; Cell Proliferation; Gene Expression Regulation, Neoplastic; Female
Rights: ©2012 American Association for Cancer Research
RMID: 0020121709
DOI: 10.1158/1055-9965.EPI-12-0173
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Appears in Collections:Medicine publications

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