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Type: Journal article
Title: DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes
Author: Shibuya, A.
Campbell, D.
Hannum, C.
Yssel, H.
Franz-Bacon, K.
McClanahan, T.
Kitamura, T.
Nicholl, J.
Sutherland, G.
Lanier, L.
Phillips, J.
Citation: Immunity, 1996; 4(6):573-581
Publisher: CELL PRESS
Issue Date: 1996
ISSN: 1074-7613
Statement of
Akira Shibuya, David Campbell, Charles Hannum, Hans Yssel, Karin Franz-Bacon, Terrill McClanahan, Toshio Kitamura, Jillian Nicholl, Grant R Sutherland, Lewis L Lanier, Joseph H Phillips
Abstract: Intercellular adhesion molecules play an important role in the generation of T lymphocyte-mediated immune responses. Here, we describe a novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes. DNAM-1 is a 65 kDa transmembrane glycoprotein consisting of 318 aa including two immunoglobulin-like domains. Anti-DNAM-1 monoclonal antibody (MAb) inhibits T and NK cell-mediated cytotoxicity against a variety of tumor cell targets and blocks cytokine production by alloantigen-specific T cells. In addition, DNAM-1 is a tyrosine-phosphorylated signal-transducing molecule that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity.
Keywords: B-Lymphocytes
Killer Cells, Natural
T-Lymphocytes, Cytotoxic
Cell Adhesion Molecules
Membrane Proteins
DNA, Complementary
Antigens, Differentiation, T-Lymphocyte
Antigens, Surface
Cloning, Molecular
Signal Transduction
Cytotoxicity, Immunologic
Amino Acid Sequence
Base Sequence
Molecular Sequence Data
DOI: 10.1016/S1074-7613(00)70060-4
Appears in Collections:Aurora harvest
Paediatrics publications

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