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Type: Conference paper
Title: Joint symbolic dynamics as a model-free approach to study interdependence in cardio-respiratory time series
Author: Baumert, M.
Brown, R.
Duma, S.
Broe, G.
Kabir, M.
Macefield, V.
Citation: Engineering Innovation in Global Health: Proceedings of the 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, held in San Diego, August 28-September 1, 2012: pp. 3680-3683
Publisher: IEEE
Publisher Place: CD
Issue Date: 2012
Series/Report no.: IEEE Engineering in Medicine and Biology Society Conference Proceedings
ISBN: 9781457717871
ISSN: 1557-170X
Conference Name: Annual International Conference of the IEEE Engineering in Medicine and Biology Society (34th : 2012 : San Diego)
Statement of
Mathias Baumert, Rachael Brown, Stephen Duma, G. Anthony Broe, Muammar Muhammad Kabir and Vaughan Macefield
Abstract: Heart rate and respiration display fluctuations that are interlinked by central regulatory mechanisms of the autonomic nervous system (ANS). Joint assessment of respiratory time series along with heart rate variability (HRV) may therefore provide information on ANS dysfunction. The aim of this study was to investigate cardio-respiratory interaction in patients with Parkinson’s disease (PD), a neurodegenerative disorder that is associated with progressive ANS dysfunction. Short-term ECG and respiration were recorded in 25 PD patients and 28 healthy controls during rest. To assess ANS dysfunction we analyzed joint symbolic dynamics of heart rate and respiration, cardio-respiratory synchrograms along with heart rate variability. Neither HRV nor cardio-respiratory synchrograms were significantly altered in PD patients. Symbolic analysis, however, identified a significant reduction in cardio-respiratory interactions in PD patients compared to healthy controls (16 ± 3.6 % vs. 20 ± 6.1 %; p = 0.02). In conclusion, joint symbolic analysis of cardio-respiratory dynamics provides a powerful tool to detect early signs of autonomic nervous system dysfunction in Parkinson’s disease patients at an early stage of the disease.
Keywords: Nonlinear dynamics in biomedical signals; nonstationary processing of biomedical signals; phas locking estimation in biosignal analysis
Rights: Copyright © 2012 IEEE Engineering in Medicine and Biology Society. All rights reserved.
RMID: 0020122321
DOI: 10.1109/EMBC.2012.6346765
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Appears in Collections:Electrical and Electronic Engineering publications

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