Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/73922
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dc.contributor.author | Parker, L. | - |
dc.contributor.author | Ascher, D. | - |
dc.contributor.author | Chen, G. | - |
dc.contributor.author | Miles, L. | - |
dc.contributor.author | Harris, H. | - |
dc.contributor.author | Parker, M. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Inorganic Biochemistry, 2012; 115:138-147 | - |
dc.identifier.issn | 0162-0134 | - |
dc.identifier.issn | 1873-3344 | - |
dc.identifier.uri | http://hdl.handle.net/2440/73922 | - |
dc.description.abstract | In this mini-review we focus on metal interactions with proteins with a particular emphasis on the evident synergism between different biophysical approaches toward understanding metallobiology. We highlight three recent examples from our own laboratory. Firstly, we describe metallodrug interactions with glutathione S-transferases, an enzyme family known to attack commonly used anti-cancer drugs. We then describe a protein target for memory enhancing drugs called insulin-regulated aminopeptidase in which zinc plays a role in catalysis and regulation. Finally we describe our studies on a protein, amyloid precursor protein, that appears to play a central role in Alzheimer's disease. Copper ions have been implicated in playing both beneficial and detrimental roles in the disease by binding to different regions of this protein. | - |
dc.description.statementofresponsibility | Lorien J. Parker, David B. Ascher, Chen Gao, Luke A. Miles, Hugh H. Harris, Michael W. Parker | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Science Inc | - |
dc.rights | Copyright © 2012 Elsevier Inc. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jinorgbio.2012.02.015 | - |
dc.subject | Amyloid precursor protein | - |
dc.subject | Glutathione transferase | - |
dc.subject | Insulin-regulated aminopeptidase | - |
dc.subject | X-ray absorption spectroscopy | - |
dc.subject | X-ray crystallography | - |
dc.title | Structural approaches to probing metal interaction with proteins | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jinorgbio.2012.02.015 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Harris, H. [0000-0002-3472-8628] | - |
Appears in Collections: | Aurora harvest 4 Chemistry publications Environment Institute publications IPAS publications |
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