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Type: Journal article
Title: Effects of fat, protein, and carbohydrate and protein load on appetite, plasma cholecystokinin, peptide YY, and ghrelin, and energy intake in lean and obese men
Author: Brennan, I.
Luscombe-Marsh, N.
Seimon, R.
Otto, B.
Horowitz, M.
Wishart, J.
Feinle-Bisset, C.
Citation: American Journal of Physiology: Gastrointestinal and Liver Physiology, 2012; 303(1):129-140
Publisher: Amer Physiological Soc
Issue Date: 2012
ISSN: 0193-1857
Statement of
Ixchel M. Brennan, Natalie D. Luscombe-Marsh, Radhika V. Seimon, Bärbel Otto, Michael Horowitz, Judith M. Wishart and Christine Feinle-Bisset
Abstract: While protein is regarded as the most satiating macronutrient, many studies have employed test meals that had very high and unsustainable protein contents. Furthermore, the comparative responses between lean and obese subjects and the relationships between energy intake suppression and gut hormone release remain unclear. We evaluated the acute effects of meals with modest variations in 1) fat, protein, and carbohydrate content and 2) protein load on gastrointestinal hormones, appetite, and subsequent energy intake in lean and obese subjects. Sixteen lean and sixteen obese men were studied on four occasions. Following a standardized breakfast, they received for lunch: 1) high-fat (HF), 2) high-protein (HP), 3) high-carbohydrate/low-protein (HC/LP), or 4) adequate-protein (AP) isocaloric test meals. Hunger, fullness, and gut hormones were measured throughout, and at t = 180 min energy intake at a buffet meal was quantified. In lean subjects, hunger was less and fullness greater following HF, HP, and AP compared with HC/LP meals, and energy intake was less following HF and HP compared with HC meals (P < 0.05). In the obese subjects, hunger was less following HP compared with HF, HC/LP, and AP meals, and energy intake was less following HP and AP compared with HF and HC meals (P < 0.05). There were no major differences in hormone responses to the meals among subject groups, but the CCK and ghrelin responses to HP and AP were sustained in both groups. In conclusion, HP meals suppress energy intake in lean and obese subjects, an effect potentially mediated by CCK and ghrelin, while obese individuals appear to be less sensitive to the satiating effects of fat.
Keywords: Humans
Gastrointestinal Hormones
Peptide YY
Dietary Carbohydrates
Dietary Fats
Dietary Proteins
Satiety Response
Energy Intake
Postprandial Period
Middle Aged
Young Adult
Rights: Copyright © 2012 the American Physiological Society
DOI: 10.1152/ajpgi.00478.2011
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