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|Web of Science®
|Toxicity of the cyanobacterium Limnothrix AC0243 to male Balb/c mice
|Water Research, 2012; 46(5):1576-1583
|Pergamon-Elsevier Science Ltd
|Andrew Humpage, Ian Falconer, Catherine Bernard, Suzanne Froscio and Larelle Fabbro
|A growing list of freshwater cyanobacteria are known to produce toxic agents, a fact which makes these organisms of concern to water authorities. A cultured strain of Limnothrix (AC0243) was recently shown to have toxic effects in in vitro bioassays. It did not produce any of the known cyanobacterial toxins. The intrapertoneal toxicity of aqueous extracts of the material was therefore tested in mice to determine whether the observed effects might be of public health relevance to drinking water supplies. The results indicate that Limnothrix AC0243 is acutely toxic to mice, causing widespread cellular necrosis in the liver, kidneys and gastrointestinal tract within 24 h of exposure. Sub-lethal effects lasted at least 7 d. These results suggest that Limnothrix AC0243 produces a novel toxin ("Limnothrixin") and that further work is therefore urgently required to quantify the potential public health implications.
Mice, Inbred BALB C
|© 2011 Elsevier Ltd. All rights reserved
|Appears in Collections:
Environment Institute publications
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