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Type: Journal article
Title: Toxicity of the cyanobacterium Limnothrix AC0243 to male Balb/c mice
Author: Humpage, A.
Falconer, I.
Bernard, C.
Froscio, S.
Fabbro, L.
Citation: Water Research, 2012; 46(5):1576-1583
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2012
ISSN: 0043-1354
Statement of
Andrew Humpage, Ian Falconer, Catherine Bernard, Suzanne Froscio and Larelle Fabbro
Abstract: A growing list of freshwater cyanobacteria are known to produce toxic agents, a fact which makes these organisms of concern to water authorities. A cultured strain of Limnothrix (AC0243) was recently shown to have toxic effects in in vitro bioassays. It did not produce any of the known cyanobacterial toxins. The intrapertoneal toxicity of aqueous extracts of the material was therefore tested in mice to determine whether the observed effects might be of public health relevance to drinking water supplies. The results indicate that Limnothrix AC0243 is acutely toxic to mice, causing widespread cellular necrosis in the liver, kidneys and gastrointestinal tract within 24 h of exposure. Sub-lethal effects lasted at least 7 d. These results suggest that Limnothrix AC0243 produces a novel toxin ("Limnothrixin") and that further work is therefore urgently required to quantify the potential public health implications.
Keywords: Gastrointestinal Tract
Mice, Inbred BALB C
Bacterial Toxins
Marine Toxins
Protein Biosynthesis
Cyanobacteria Toxins
Rights: © 2011 Elsevier Ltd. All rights reserved
DOI: 10.1016/j.watres.2011.11.019
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Appears in Collections:Aurora harvest
Environment Institute publications
Pharmacology publications

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