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Type: Journal article
Title: Biomimetic total synthesis of (±)-garcibracteatone
Other Titles: Biomimetic total synthesis of (+/-)-garcibracteatone
Author: Pepper, H.
Lam, H.
Bloch, W.
George, J.
Citation: Organic Letters, 2012; 14(19):5162-5164
Publisher: Amer Chemical Soc
Issue Date: 2012
ISSN: 1523-7060
Statement of
Henry P. Pepper, Hiu C. Lam, Witold M. Bloch, and Jonathan H. George
Abstract: The polycyclic polyprenylated acylphloroglucinol natural product garcibracteatone has been synthesized in four steps from phloroglucinol, using a strategy based on biosynthetic speculation. The key biomimetic transformation is a cascade of 7-endo-trig and 5-exo-trig radical cyclizations followed by a terminating aromatic substitution reaction.
Keywords: Polycyclic Compounds; Molecular Structure; Models, Molecular; Biomimetic Materials
Rights: Copyright © 2012 American Chemical Society
RMID: 0020122385
DOI: 10.1021/ol302524q
Appears in Collections:Chemistry publications
IPAS publications

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