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Type: Journal article
Title: Beat-to-beat vectorcardiographic analysis of ventricular depolarization and repolarization in myocardial infarction
Author: Hasan, M.
Abbott, D.
Baumert, M.
Citation: PLoS One, 2012; 7(11):1-10
Publisher: Public Library of Science
Issue Date: 2012
ISSN: 1932-6203
Editor: Frangogiannis, N.
Statement of
Muhammad A. Hasan, Derek Abbott and Mathias Baumert
Abstract: OBJECTIVES: Increased beat-to-beat variability in the QT interval has been associated with heart disease and mortality. The purpose of this study was to investigate the beat-to-beat spatial and temporal variations of ventricular depolarization and repolarization in vectorcardiogram (VCG) for characterising myocardial infarction (MI) patients. METHODS: Standard 12-lead ECGs of 84 MI patients (22 f, 63±12 yrs; 62 m, 56±10 yrs) and 69 healthy subjects (17 f, 42±18 yrs; 52 m, 40±13 yrs) were investigated. To extract the beat-to-beat QT intervals, a template-matching algorithm and the singular value decomposition method have been applied to synthesise the ECG data to VCG. Spatial and temporal variations in the QRS complex and T-wave loops were studied by investigating several descriptors (point-to-point distance variability, mean loop length, T-wave morphology dispersion, percentage of loop area, total cosine R-to-T). RESULTS: Point-to-point distance variability of QRS and T-loops (0.13±.04 vs. 0.10±0.04, p<0.0001 and 0.16±.07 vs. 0.13±.06, p<0.05) were significantly larger in the MI group than in the control group. The average T-wave morphology dispersion was significantly higher in the MI group than in the control group (62±8 vs. 38±16, p<.0001). Further, its beat-to-beat variability appeared significantly lower in the MI group than in the control group (12±5 v. 15±6u, p<0.005). Moreover, the average percentage of the T-loop area was found significantly lower in the MI group than the controls (46±17 vs. 55±15, p<.001). Finally, the average and beat-to-beat variability of total cosine R-to-T were not found statistically significant between both groups. CONCLUSIONS: Beat-to-beat assessment of VCG parameters may have diagnostic attributes that might help in identifying MI patients.
Keywords: Humans
Heart Ventricles
Myocardial Infarction
Case-Control Studies
Middle Aged
Rights: © 2012 Hasan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
DOI: 10.1371/journal.pone.0049489
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Electrical and Electronic Engineering publications

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