Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7544
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Type: Journal article
Title: Insulin-like growth factor-I and the gastrointestinal system: Therapeutic indications and safety implications
Author: Howarth, G.
Citation: Journal of Nutrition, 2003; 133(7):2109-2112
Publisher: Amer Inst Nutrition
Issue Date: 2003
ISSN: 0022-3166
1541-6100
Abstract: Following the identification of insulin-like growth factor-I (IGF-I) as a potent trophic factor for the intestine over a decade ago, therapeutic indications have been identified for a range of candidate bowel disorders and diseases in which accelerated intestinal repair is desirable. Subsequent experimental studies in experimentally-induced animal models and genetically-modified mice have supported a therapeutic role for IGF-I in facilitated repair processes in gastrointestinal disorders including radiation enteritis, chemotherapy-induced mucositis and inflammatory bowel disease, conditions associated with either the pre-existence of malignancy or a predisposition to develop neoplasia. Moreover, recent evidence from in vitro, in vivo and human population studies is suggestive of an active role for IGF-I in the development and progression of certain cancers, and although causality remains unproven, antagonism of IGF-I action is being pursued as a potential chemo-preventive strategy. Novel milk and colostrum-derived bioactive formulations containing IGF-I are being developed as adjunctive treatment modalities for certain bowel disorders. Understanding the precise role of the IGF axis in cancer will either identify antagonism of the IGF-I/receptor interaction as an important approach in cancer prevention and risk reduction, or alternatively, support further development of IGF-I as a promising treatment modality for acute gastrointestinal disease.
Keywords: Insulin-like growth factor-I; intestine; disease; treatment; cancer; risk
RMID: 0020030525
DOI: 10.1093/jn/133.7.2109
Published version: http://jn.nutrition.org/cgi/content/abstract/133/7/2109
Appears in Collections:Paediatrics publications
Physiology publications

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