Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/75472
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: The effect of obesity on polycystic ovary syndrome: a systematic review and meta-analysis
Author: Lim, S.
Norman, R.
Davies, M.
Moran, L.
Citation: Obesity Reviews, 2013; 14(2):95-109
Publisher: Wiley-Blackwell Publishing Ltd
Issue Date: 2013
ISSN: 1467-789X
1467-789X
Statement of
Responsibility: 
S. S. Lim, R. J. Norman, M. J. Davies and L. J. Moran
Abstract: While many women with polycystic ovary syndrome (PCOS) are overweight, obese or centrally obese, the effect of excess weight on the outcomes of PCOS is inconsistent. The review aimed to assess the effects of overweight, obesity and central obesity on the reproductive, metabolic and psychological features of PCOS. MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL) and PSYCINFO were searched for studies reporting outcomes according to body mass index categories or body fat distribution. Data were presented as mean difference or risk ratio (95% confidence interval). This review included 30 eligible studies. Overweight or obese women with PCOS had decreased sex hormone-binding globulin (SHBG), increased total testosterone, free androgen index, hirsutism, fasting glucose, fasting insulin, homeostatic model assessment-insulin resistance index and worsened lipid profile. Obesity significantly worsened all metabolic and reproductive outcomes measured except for hirsutism when compared to normal weight women with PCOS. Overweight women had no differences in total testosterone, hirsutism, total-cholesterol and low-density lipoprotein-cholesterol compared to normal weight women and no differences in SHBG and total testosterone compared to obese women. Central obesity was associated with higher fasting insulin levels. These results suggest that prevention and treatment of obesity is important for the management of PCOS.
Keywords: Central obesity; obesity; overweight; polycystic ovary syndrome.
Rights: © 2012 The Authors
RMID: 0020123091
DOI: 10.1111/j.1467-789x.2012.01053.x
Appears in Collections:Obstetrics and Gynaecology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.