Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7568
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Type: Journal article
Title: Bowel dysfunction in cystic fibrosis: importance of breath testing
Author: Lewindon, P.
Robb, T.
Moore, D.
Davidson, G.
Martin, A.
Citation: Journal of Paediatrics and Child Health, 1998; 34(1):79-82
Publisher: BLACKWELL SCIENCE
Issue Date: 1998
ISSN: 1034-4810
1440-1754
Abstract: <h4>Objective</h4>To investigate the prevalence of carbohydrate malabsorption and bacterial overgrowth in children with cystic fibrosis (CF) and abnormal stool pattern referred for breath hydrogen testing.<h4>Methods</h4>Results from 89 tests using lactose, sucrose and lactulose in 54 children with CF were compared with 5430 tests on children with non-CF-related stool abnormalities.<h4>Results</h4>Children with CF were more frequently unable to ferment lactulose to hydrogen (39% vs. 20%, P<0.03); they had significantly longer oro-caecal transit times (mean 99 vs. 68 min, P<0.0003); they had a higher incidence of bacterial overgrowth (32% vs. 7%, P<0.003) and sucrose malabsorption (47% vs. 14.5%, P<0.004); but they had no increase in lactose malabsorption (40% vs. 31%). Children with bacterial overgrowth in both groups had longer transit times (CF 123 min, non-CF 108 min) compared to the non-CF children without overgrowth (68 min) and reference normal children (69 min).<h4>Conclusions</h4>Bacterial overgrowth and carbohydrate malabsorption, particularly of sucrose, should be considered when assessing children with CF and abnormal stool patterns.
Keywords: Digestive System; Humans; Intestinal Diseases; Malabsorption Syndromes; Cystic Fibrosis; Hydrogen; Lactose; Sucrose; Breath Tests; Gastrointestinal Transit; Child; Child, Preschool; Infant; Carbohydrate Metabolism
RMID: 0030005503
DOI: 10.1046/j.1440-1754.1998.00159.x
Appears in Collections:Paediatrics publications

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