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https://hdl.handle.net/2440/7568
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Type: | Journal article |
Title: | Bowel dysfunction in cystic fibrosis: importance of breath testing |
Author: | Lewindon, P. Robb, T. Moore, D. Davidson, G. Martin, A. |
Citation: | Journal of Paediatrics and Child Health, 1998; 34(1):79-82 |
Publisher: | BLACKWELL SCIENCE |
Issue Date: | 1998 |
ISSN: | 1034-4810 1440-1754 |
Abstract: | <h4>Objective</h4>To investigate the prevalence of carbohydrate malabsorption and bacterial overgrowth in children with cystic fibrosis (CF) and abnormal stool pattern referred for breath hydrogen testing.<h4>Methods</h4>Results from 89 tests using lactose, sucrose and lactulose in 54 children with CF were compared with 5430 tests on children with non-CF-related stool abnormalities.<h4>Results</h4>Children with CF were more frequently unable to ferment lactulose to hydrogen (39% vs. 20%, P<0.03); they had significantly longer oro-caecal transit times (mean 99 vs. 68 min, P<0.0003); they had a higher incidence of bacterial overgrowth (32% vs. 7%, P<0.003) and sucrose malabsorption (47% vs. 14.5%, P<0.004); but they had no increase in lactose malabsorption (40% vs. 31%). Children with bacterial overgrowth in both groups had longer transit times (CF 123 min, non-CF 108 min) compared to the non-CF children without overgrowth (68 min) and reference normal children (69 min).<h4>Conclusions</h4>Bacterial overgrowth and carbohydrate malabsorption, particularly of sucrose, should be considered when assessing children with CF and abnormal stool patterns. |
Keywords: | Digestive System Humans Intestinal Diseases Malabsorption Syndromes Cystic Fibrosis Hydrogen Lactose Sucrose Breath Tests Gastrointestinal Transit Child Child, Preschool Infant Carbohydrate Metabolism |
DOI: | 10.1046/j.1440-1754.1998.00159.x |
Published version: | http://dx.doi.org/10.1046/j.1440-1754.1998.00159.x |
Appears in Collections: | Aurora harvest Paediatrics publications |
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