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Type: Journal article
Title: Reproducibility of the 13C-octanoic acid breath test for assessment of gastric emptying in healthy preterm infants
Author: Barnett, C.
Snel, A.
Omari, T.
Davidson, G.
Haslam, R.
Butler, R.
Citation: Journal of Pediatric Gastroenterology and Nutrition, 1999; 29(1):26-30
Issue Date: 1999
ISSN: 0277-2116
Abstract: <h4>Background</h4>The 13C-octanoic acid breath test has been used to measure gastric emptying in preterm infants, but the reproducibility of the test has not been evaluated in this population.<h4>Methods</h4>Fifty-six paired breath test analyses were performed on 28 healthy preterm infants 1 to 5 days apart using the same food type, volume, and energy content for each paired sample. Breath samples were taken before the feeding, at 5-minute intervals after feeding for 30 minutes, then each 15 minutes for 4 hours. Samples were analyzed using an isotope-ratio mass spectrometer, and 3C recovery was used to calculate values for gastric-emptying coefficient and gastric half-emptying time.<h4>Results</h4>There was no significant difference between test results on different days in the paired samples studied. gastric-emptying coefficients for the first and subsequent samples were 2.6+/-0.1 (mean+/-SEM) and 2.7+/-0.1, respectively, and half-emptying times were 44.5+/-3.7 minutes and 41.4+/-3.2 minutes.<h4>Conclusion</h4>The 13C-octanoic acid breath test is a reliable, noninvasive, and reproducible measure of gastric emptying in preterm infants that should have wide application for use in this population.
Keywords: Humans
Carbon Dioxide
Carbon Isotopes
Breath Tests
Enteral Nutrition
Reproducibility of Results
Gastric Emptying
Models, Theoretical
Infant, Newborn
Infant, Premature
Mass Spectrometry
DOI: 10.1097/00005176-199907000-00009
Appears in Collections:Aurora harvest
Paediatrics publications

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