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https://hdl.handle.net/2440/7592
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Type: | Journal article |
Title: | Reproducibility of the 13C-octanoic acid breath test for assessment of gastric emptying in healthy preterm infants |
Author: | Barnett, C. Snel, A. Omari, T. Davidson, G. Haslam, R. Butler, R. |
Citation: | Journal of Pediatric Gastroenterology and Nutrition, 1999; 29(1):26-30 |
Publisher: | LIPPINCOTT WILLIAMS & WILKINS |
Issue Date: | 1999 |
ISSN: | 0277-2116 1536-4801 |
Abstract: | <h4>Background</h4>The 13C-octanoic acid breath test has been used to measure gastric emptying in preterm infants, but the reproducibility of the test has not been evaluated in this population.<h4>Methods</h4>Fifty-six paired breath test analyses were performed on 28 healthy preterm infants 1 to 5 days apart using the same food type, volume, and energy content for each paired sample. Breath samples were taken before the feeding, at 5-minute intervals after feeding for 30 minutes, then each 15 minutes for 4 hours. Samples were analyzed using an isotope-ratio mass spectrometer, and 3C recovery was used to calculate values for gastric-emptying coefficient and gastric half-emptying time.<h4>Results</h4>There was no significant difference between test results on different days in the paired samples studied. gastric-emptying coefficients for the first and subsequent samples were 2.6+/-0.1 (mean+/-SEM) and 2.7+/-0.1, respectively, and half-emptying times were 44.5+/-3.7 minutes and 41.4+/-3.2 minutes.<h4>Conclusion</h4>The 13C-octanoic acid breath test is a reliable, noninvasive, and reproducible measure of gastric emptying in preterm infants that should have wide application for use in this population. |
Keywords: | Humans Carbon Dioxide Carbon Isotopes Caprylates Breath Tests Enteral Nutrition Reproducibility of Results Gastric Emptying Models, Theoretical Infant, Newborn Infant, Premature Mass Spectrometry |
DOI: | 10.1097/00005176-199907000-00009 |
Published version: | http://dx.doi.org/10.1097/00005176-199907000-00009 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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