Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/7617
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Type: Journal article
Title: Characterization of esophageal body and lower esophageal sphincter motor function in the very premature neonate
Author: Omari, T.
Benninga, M.
Barnett, C.
Haslam, R.
Davidson, G.
Dent, J.
Citation: Journal of Pediatrics, 1999; 135(4):517-521
Publisher: Mosby
Issue Date: 1999
ISSN: 0022-3476
1097-6833
Statement of
Responsibility: 
Taher I. Omari, Marc A. Benninga, Christopher P. Barnett, Ross R. Haslam, Geoff P. Davidson, and John Dent
Abstract: <h4>Objectives</h4>To characterize esophageal body and lower esophageal sphincter (LES) motor function in very premature infants.<h4>Study design</h4>Esophageal manometry was performed in 12 very premature infants of 26 to 33 weeks' postmenstrual age (PMA) (body weights of 610-1360 g). Esophageal motor patterns were recorded for 30 minutes with a perfused micromanometric sleeve assembly (outer diameter, 2.0 mm).<h4>Results</h4>Esophageal pressure waves triggered by dry swallows were predominantly (84%) peristaltic in propagation sequence. All infants showed tonic LES contraction; the mean resting LES pressure (LESP) for individual infants ranged from 5.0 +/- 4.1 mm Hg to 20.0 +/- 4.8 mm Hg. In all infants the LES relaxed (duration, 5.8 +/- 3.0 seconds; nadir pressure, 1.8 +/- 2.6 mm Hg) in response to pharyngeal swallows. Transient LES relaxations (TLESRs) (duration, 21.7 +/- 8.7 seconds; nadir pressure, 0.1 +/- 1.8 mm Hg) occurred on average 2.6 +/- 1.6 times per study; 86% of these relaxations triggered esophageal body common cavity events known to be associated with gastroesophageal reflux.<h4>Conclusions</h4>Esophageal motor function is well developed in very premature infants. Our data also suggest that TLESR is the predominant mechanism of reflux in these babies.
Keywords: Esophagus
Esophagogastric Junction
Humans
Manometry
Peristalsis
Muscle Contraction
Pressure
Infant, Newborn
Infant, Very Low Birth Weight
Infant, Premature
Rights: Copyright © 1999 Mosby, Inc. All rights reserved.
DOI: 10.1016/S0022-3476(99)70178-2
Appears in Collections:Aurora harvest 4
Paediatrics publications

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