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https://hdl.handle.net/2440/7697
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Tarran, R. | - |
dc.contributor.author | Grubb, B. | - |
dc.contributor.author | Parsons, D. | - |
dc.contributor.author | Picher, M. | - |
dc.contributor.author | Hirsch, A. | - |
dc.contributor.author | Davis, C. | - |
dc.contributor.author | Boucher, R. | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Molecular Cell, 2001; 8(1):149-158 | - |
dc.identifier.issn | 1097-2765 | - |
dc.identifier.issn | 1097-4164 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7697 | - |
dc.description.abstract | There is controversy over whether abnormalities in the salt concentration or volume of airway surface liquid (ASL) initiate cystic fibrosis (CF) airway disease. In vivo studies of CF mouse nasal epithelia revealed an increase in goblet cell number that was associated with decreased ASL volume rather than abnormal [Cl−]. Aerosolization of osmolytes in vivo failed to raise ASL volume. In vitro studies revealed that osmolytes and pharmacological agents were effective in producing isotonic volume responses in human airway epithelia but were typically short acting and less effective in CF cultures with prolonged volume hyperabsorption and mucus accumulation. These data show that (1) therapies can be designed to normalize ASL volume, without producing deleterious compositional changes in ASL, and (2) therapeutic efficacy will likely depend on development of long-acting pharmacologic agents and/or an increased efficiency of osmolyte delivery. | - |
dc.language.iso | en | - |
dc.publisher | Cell Press | - |
dc.rights | Copyright © 2001 Cell Press. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/s1097-2765(01)00286-6 | - |
dc.subject | Goblet Cells | - |
dc.subject | Nasal Mucosa | - |
dc.subject | Respiratory Mucosa | - |
dc.subject | Cells, Cultured | - |
dc.subject | Mucus | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Cystic Fibrosis | - |
dc.subject | Disease Models, Animal | - |
dc.subject | Sodium Chloride | - |
dc.subject | Amiloride | - |
dc.subject | Raffinose | - |
dc.subject | Uridine Triphosphate | - |
dc.subject | Diuretics | - |
dc.subject | Pulmonary Surfactants | - |
dc.subject | Aerosols | - |
dc.subject | Microscopy, Confocal | - |
dc.subject | Microdialysis | - |
dc.subject | Ion Transport | - |
dc.subject | Osmolar Concentration | - |
dc.title | The CF salt controversy: In vivo observations and therapeutic approaches | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S1097-2765(01)00286-6 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Parsons, D. [0000-0003-1746-3290] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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