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Type: Journal article
Title: Current and emerging immunotherapeutic approaches to treat and prevent peanut allergy
Author: Miller, D.
Brown, M.
Howley, P.
Hayball, J.
Citation: Expert Review of Vaccines, 2012; 11(12):1471-1481
Publisher: Future Drugs Ltd.
Issue Date: 2012
ISSN: 1476-0584
Statement of
Darren S. Miller, Michael P. Brown, Paul M. Howley and John D. Hayball
Abstract: Peanut-allergen hypersensitivity reactions, which can result in anaphylactic episodes and death, affect approximately 1% of the general population. Currently, strict avoidance of allergenic food is the only available treatment for this food-induced allergic reaction; however, the innocuous presence of trace amounts of peanut protein contaminating food products makes avoidance extremely difficult, especially in children. Therefore, safe and inexpensive therapeutic strategies aimed at prevention and treatment of peanut allergies is urgently required. This review summarizes the current state of knowledge of adaptive immune recognition and responsiveness to peanut allergens and how this can be integrated and subverted into new therapeutic treatment regimens for these dangerous allergic responses. The potential for new strategic vaccination-based interventions to either moderate or prevent these types of responses from occurring is also discussed.
Keywords: CD4-Positive T-Lymphocytes
Peanut Hypersensitivity
Immunoglobulin E
Membrane Proteins
Plant Proteins
Vaccines, DNA
Risk Factors
Antigens, Plant
Clinical Trials as Topic
Adaptive Immunity
Antibodies, Monoclonal, Humanized
Rights: Copyright status unknown
DOI: 10.1586/ERV.12.119
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