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|Title:||Orbital cavernous haemangiomas: immunohistochemical study of proliferative capacity, vascular differentiation and hormonal receptor status|
|Citation:||Orbit, 2012; 31(6):386-389|
|Publisher:||Taylor & Francis The Netherlands|
|Aanchal Gupta, Venkatesh C. Prabhakaran, Tom Dodd, Garry Davis, and Dinesh Selva|
|Abstract:||Background/Aims: Immunohistochemical characterisation of orbital cavernous haemangiomas (CHs) with respect to proliferative capacity, hormone receptor status and vascular differentiation. Methods: Eleven cases of orbital CHs were reviewed. Immunohistochemical stains for Mib-1, proliferating cell nuclear antigen (PCNA), Bcl-2, estrogen and progesterone receptors (ER & PR), CD31, D2-40, and VEGF were investigated in 11 specimens. Results: Immunohistochemical staining revealed positivity for PCNA in ten of the 11 cases (91%). Bcl-2 was positive in 8 cases (73%). VEGF and PR were each weakly positive in 3 cases. All cases were negative for Mib-1, ER and D2-40. The staining was localized around the endothelium. Conclusion: This is the first study to characterise in detail the immunohistochemical features of orbital CHs. The proliferative markers PCNA and Mib-1 show discordant expression in these lesions and the expression of PCNA and Bcl-2 in the absence of Mib-1 is indicative of low proliferative potential. Small subsets of these tumors express PR and VEGF, which may partly explain the proliferative capacity of some orbital CHs.|
|Keywords:||Cavernous haemangioma; Immunohistochemistry; Differentiation; Proliferation|
|Rights:||© 2012 Informa Healthcare USA, Inc.|
|Appears in Collections:||Opthalmology & Visual Sciences publications|
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