Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/77439
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Type: Journal article
Title: Orbital cavernous haemangiomas: immunohistochemical study of proliferative capacity, vascular differentiation and hormonal receptor status
Author: Gupta, A.
Prabhakaran, V.
Dodd, T.
Davis, G.
Selva-Nayagam, D.
Citation: Orbit, 2012; 31(6):386-389
Publisher: Taylor & Francis The Netherlands
Issue Date: 2012
ISSN: 0167-6830
1744-5108
Statement of
Responsibility: 
Aanchal Gupta, Venkatesh C. Prabhakaran, Tom Dodd, Garry Davis, and Dinesh Selva
Abstract: Background/Aims: Immunohistochemical characterisation of orbital cavernous haemangiomas (CHs) with respect to proliferative capacity, hormone receptor status and vascular differentiation. Methods: Eleven cases of orbital CHs were reviewed. Immunohistochemical stains for Mib-1, proliferating cell nuclear antigen (PCNA), Bcl-2, estrogen and progesterone receptors (ER & PR), CD31, D2-40, and VEGF were investigated in 11 specimens. Results: Immunohistochemical staining revealed positivity for PCNA in ten of the 11 cases (91%). Bcl-2 was positive in 8 cases (73%). VEGF and PR were each weakly positive in 3 cases. All cases were negative for Mib-1, ER and D2-40. The staining was localized around the endothelium. Conclusion: This is the first study to characterise in detail the immunohistochemical features of orbital CHs. The proliferative markers PCNA and Mib-1 show discordant expression in these lesions and the expression of PCNA and Bcl-2 in the absence of Mib-1 is indicative of low proliferative potential. Small subsets of these tumors express PR and VEGF, which may partly explain the proliferative capacity of some orbital CHs.
Keywords: Cavernous haemangioma; Immunohistochemistry; Differentiation; Proliferation
Rights: © 2012 Informa Healthcare USA, Inc.
RMID: 0020127016
DOI: 10.3109/01676830.2012.711887
Appears in Collections:Opthalmology & Visual Sciences publications

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