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Type: Journal article
Title: bcl-w, a novel member of the bcl-2 family, promotes cell survival
Author: Gibson, L.
Holmgreen, S.
Huang, D.
Bernand, O.
Copeland, N.
Jenkins, N.
Sutherland, G.
Baker, E.
Adams, J.
Cory, S.
Citation: Oncogene, 1996; 13(4):665-675
Issue Date: 1996
ISSN: 0950-9232
Statement of
Gibson, L ; Holmgreen, S P ; Huang, D C ; Bernard, O ; Copeland, N G ; Jenkins, N A ; Sutherland, G R ; Baker, E ; Adams, J M ; Cory, S
Abstract: The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. Several homologues of bcl-2 are now known. Using a PCR-based strategy we cloned a novel member of this gene family, denoted bcl-w. The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor alpha gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Comparison of the expected amino acid sequence of Bcl-w with that of these relatives helps to delineate residues likely to convey survival or anti-survival function. While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene.
Keywords: Chromosomes, Human, Pair 14
Mice, Inbred C57BL
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
DNA, Complementary
Chromosome Mapping
Cloning, Molecular
Cell Survival
Amino Acid Sequence
Base Sequence
Sequence Homology, Amino Acid
Multigene Family
Molecular Sequence Data
Apoptosis Regulatory Proteins
Proto-Oncogene Mas
Appears in Collections:Aurora harvest 4
Paediatrics publications

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