Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/7771
Citations
Scopus Web of ScienceĀ® Altmetric
?
?
Type: Journal article
Title: Detection and significance of the potentially pathogenic amoeboflagellate Naegleria italica in Australia
Author: Robinson, B.
Monis, P.
Henderson, M.
Gelonese, S.
Ferrante, A.
Citation: Parasitology International, 2004; 53(1):23-27
Publisher: Elsevier BV
Issue Date: 2004
ISSN: 1383-5769
1873-0329
Statement of
Responsibility: 
Bret S. Robinson, Paul T. Monis, Mandy Henderson, Stella Gelonese, Antonio Ferrante
Abstract: Thermophilic amoeboflagellates in the genus Naegleria include both virulent and benign species. One of the less studied species, N. italica, has not been detected in the environment since the first reports from Italy in the 1980s; its virulence is known only from infection of laboratory mice. Two recent strains from recreational water in Western Australia (AWQC NG960, NG961) were tentatively identified as N. italica from the characteristic mobilities of seven isozymes. Sequences of the 5.8S rRNA gene and its flanking ITS aligned with a 380+bp length of the published sequence for N. italica with 98% identity. Differences from the type strain were confined to ITS2. Shorter alignments (<320 bp) were observed with other Naegleria species, corresponding to conserved regions of the 5.8S gene and ITS. Unlike the European type strain of N. italica, the Australian isolates failed to infect laboratory mice intranasally, confirming that infectivity of this species is variable and often lower than in N. fowleri.
Keywords: Animals; Mice, Inbred BALB C; Mice; Naegleria; Amebiasis; Water; DNA, Ribosomal Spacer; DNA, Protozoan; RNA, Ribosomal, 5.8S; Sequence Analysis, DNA; Virulence; Molecular Sequence Data; Western Australia; Female
RMID: 0020040212
DOI: 10.1016/j.parint.2003.10.002
Appears in Collections:Paediatrics publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.