Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/77893
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Type: Journal article
Title: Recombination gives a new insight in the effective population size and history of the Old World human populations
Author: Mele, M.
Javed, A.
Pybus, M.
Zalloua, P.
Haber, M.
Comas, D.
Netea, M.
Balanovsky, O.
Balanovska, E.
Jin, L.
Yang, Y.
Pitchappan, R.
ArunKumar, G.
Parida, L.
Calafell, F.
Bertranpetit, J.
Adler, C.
Cooper, A.
Dersarkissian, C.
Haak, W.
Citation: Molecular Biology and Evolution, 2012; 29(1):25-30
Publisher: Oxford Univ Press
Issue Date: 2012
ISSN: 0737-4038
1537-1719
Contributor: Adler, Christina Jane
Cooper, Alan
Der Sarkissian, Clio Simone Irmgard
Haak, Wolfgang
Statement of
Responsibility: 
Marta Melé, Asif Javed, Marc Pybus, Pierre Zalloua, Marc Haber, David Comas, Mihai G. Netea, Oleg Balanovsky, Elena Balanovska, Li Jin, Yajun Yang, R. M. Pitchappan, G. Arunkumar, Laxmi Parida, Francesc Calafell, Jaume Bertranpetit, and the Genographic Consortium
Abstract: The information left by recombination in our genomes can be used to make inferences on our recent evolutionary history. Specifically, the number of past recombination events in a population sample is a function of its effective population size (Ne). We have applied a method, Identifying Recombination in Sequences (IRiS), to detect specific past recombination events in 30 Old World populations to infer their Ne. We have found that sub-Saharan African populations have an Ne that is approximately four times greater than those of non-African populations and that outside of Africa, South Asian populations had the largest Ne. We also observe that the patterns of recombinational diversity of these populations correlate with distance out of Africa if that distance is measured along a path crossing South Arabia. No such correlation is found through a Sinai route, suggesting that anatomically modern humans first left Africa through the Bab-el-Mandeb strait rather than through present Egypt.
Keywords: recombination; effective population size; Out of Africa.
Description: Christina J. Adler, Alan Cooper, Clio S. I. Der Sarkissian and Wolfgang Haak are members of the Genographic Consortium
Rights: © The Author 2011. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution
RMID: 0020127608
DOI: 10.1093/molbev/msr213
Appears in Collections:Environment Institute publications
Earth and Environmental Sciences publications

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