Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/78046
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Type: Journal article
Title: Stromal miR-320 keeps an oncogenic secretome in check
Author: Khew-Goodall, Y.
Goodall, G.
Citation: Nature Cell Biology, 2012; 14(2):124-125
Publisher: Nature Publishing Group
Issue Date: 2012
ISSN: 1465-7392
1476-4679
Statement of
Responsibility: 
Yeesim Khew-Goodall and Gregory J. Goodall
Abstract: Cancer-associated fibroblasts contribute to malignancy by expressing secreted pro-tumorigenic molecules. The microRNA miR-320 is now shown to be a crucial component of a PTEN-controlled tumour-suppressive axis in stromal fibroblasts. Loss of PTEN and miR-320 induces an oncogenic secretome that reprogrammes the tumour microenvironment to promote invasion and angiogenesis.
Keywords: Animals; Humans; MicroRNAs; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Female; PTEN Phosphohydrolase; Tumor Microenvironment
Rights: © 2012 Macmillan Publishers Limited. All rights reserved.
RMID: 0020116759
DOI: 10.1038/ncb2431
Appears in Collections:Molecular and Biomedical Science publications

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