Adelaide Research & Scholarship
Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/78046
| Citations | ||
| Scopus | Web of Science® | Altmetric |
|---|---|---|
|
?
|
?
|
|
| Type: | Journal article |
| Title: | Stromal miR-320 keeps an oncogenic secretome in check |
| Author: | Khew-Goodall, Y. Goodall, G. |
| Citation: | Nature Cell Biology, 2012; 14(2):124-125 |
| Publisher: | Nature Publishing Group |
| Issue Date: | 2012 |
| ISSN: | 1465-7392 1476-4679 |
| Statement of Responsibility: | Yeesim Khew-Goodall and Gregory J. Goodall |
| Abstract: | Cancer-associated fibroblasts contribute to malignancy by expressing secreted pro-tumorigenic molecules. The microRNA miR-320 is now shown to be a crucial component of a PTEN-controlled tumour-suppressive axis in stromal fibroblasts. Loss of PTEN and miR-320 induces an oncogenic secretome that reprogrammes the tumour microenvironment to promote invasion and angiogenesis. |
| Keywords: | Animals Humans MicroRNAs Gene Expression Profiling Gene Expression Regulation, Neoplastic Female PTEN Phosphohydrolase Tumor Microenvironment |
| Rights: | © 2012 Macmillan Publishers Limited. All rights reserved. |
| DOI: | 10.1038/ncb2431 |
| Published version: | http://dx.doi.org/10.1038/ncb2431 |
| Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.