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Type: Journal article
Title: Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders
Author: Fitzgerald, M.
Hodgetts, S.
Van Den Heuvel, C.
Natoli, R.
Hart, N.
Valter, K.
Harvey, A.
Vink, R.
Provis, J.
Dunlop, S.
Citation: Reviews in the Neurosciences, 2013; 24(2):205-226
Publisher: Freund & Pettman Publishers
Issue Date: 2013
ISSN: 0334-1763
Statement of
Melinda Fitzgerald, Stuart Hodgetts, Corinna Van Den Heuvel, Riccardo Natoli, Nathan S. Hart, Krisztina Valter, Alan R. Harvey, Robert Vink, Jan Provis, Sarah A. Dunlop
Abstract: Irradiation in the red/near-infrared spectrum (R/NIR, 630–1000 nm) has been used to treat a wide range of clinical conditions, including disorders of the central nervous system (CNS), with several clinical trials currently underway for stroke and macular degeneration. However, R/NIR irradiation therapy (R/NIR-IT) has not been widely adopted in clinical practice for CNS injury or disease for a number of reasons, which include the following. The mechanism/s of action and implications of penetration have not been thoroughly addressed. The large range of treatment intensities, wavelengths and devices that have been assessed make comparisons difficult, and a consensus paradigm for treatment has not yet emerged. Furthermore, the lack of consistent positive outcomes in randomised controlled trials, perhaps due to sub-optimal treatment regimens, has contributed to scepticism. This review provides a balanced précis of outcomes described in the literature regarding treatment modalities and efficacy of R/NIR-IT for injury and disease in the CNS. We have addressed the important issues of specification of treatment parameters, penetration of R/NIR irradiation to CNS tissues and mechanism/s, and provided the necessary detail to demonstrate the potential of R/NIR-IT for the treatment of retinal degeneration, damage to white matter tracts of the CNS, stroke and Parkinson’s disease.
Keywords: irradiation therapy
Parkinson’s disease
retinal degeneration
trauma – nervous system
Rights: Copyright status unknown
DOI: 10.1515/revneuro-2012-0086
Appears in Collections:Aurora harvest 4
Pathology publications

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